Hiki Yoshiyuki, Ito Akihiko, Yamamoto Yoshihiro, Yamamoto Koichiro, Iwase Hitoo
School of Health Sciences and Medicine, Fujita Health University, Aichi, Japan.
Adv Otorhinolaryngol. 2011;72:68-70. doi: 10.1159/000324609. Epub 2011 Aug 18.
Human IgA1, which is the predominant subtype deposited in the glomeruli in IgA nephropathy (IgAN), has a unique mucin-like structure in its hinge region. Several studies suggested that the IgA1 molecules in IgAN patients had an aberrant structure of O-glycans. The paper summarizes the analyses of O-glycan structure in the IgA1 molecules taken from tonsils, sera and glomeruli of patients with IgAN. Hypoglycosylation, especially hypogalactosylation of O-glycans has been observed not only in serum and glomerular IgA1 but also in tonsillar IgA1.
人类IgA1是IgA肾病（IgAN）中沉积于肾小球的主要亚型，其铰链区具有独特的黏蛋白样结构。多项研究表明，IgAN患者的IgA1分子具有异常的O-聚糖结构。本文总结了对取自IgAN患者扁桃体、血清和肾小球的IgA1分子中O-聚糖结构的分析。不仅在血清和肾小球IgA1中，而且在扁桃体IgA1中都观察到了O-聚糖的低糖化，尤其是低半乳糖基化。
