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人类嗜酸性粒细胞和嗜碱性粒细胞的一种遗传性异常。

An inherited anomaly of human eosinophils and basophils.

作者信息

Tracey R, Smith H

出版信息

Blood Cells. 1978;4(1-2):291-300.

PMID:218657
Abstract

Inclusions staining gray or blue-gray in Romanowsky treated films were found in eosinophils and basophils in a family as an autosomal dominant anomaly without overt clinical effects. Associated with the inclusions were distinctive crystals which were different from the crystalloids of eosinophil granules and from Charcot-Leyden crystals. The restriction of the anomaly to eosinophils and basophils indicates that these are related more closely to each other than to neutrophils and mast cells, and suggests the existence of a separate stem cell for eosinophils and basophils.

摘要

在一个家族中,罗曼诺夫斯基染色的片子里嗜酸性粒细胞和嗜碱性粒细胞中发现有染成灰色或蓝灰色的包涵体,这是一种常染色体显性异常,无明显临床症状。与这些包涵体相关的是独特的晶体,它们不同于嗜酸性粒细胞颗粒的类晶体和夏科-莱登晶体。该异常仅见于嗜酸性粒细胞和嗜碱性粒细胞,这表明它们彼此之间的关系比与中性粒细胞和肥大细胞的关系更为密切,提示存在一种独立的嗜酸性粒细胞和嗜碱性粒细胞干细胞。

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