Igoshi Tadaaki, Tomisawa Narumi, Hori Yoshinori, Jinbo Yoichi
Contrib Nephrol. 2011;173:148-155. doi: 10.1159/000329053. Epub 2011 Aug 8.
Polyester polymer alloy (PEPA) membrane is developed as a synthetic polymermembrane. It consists of two polymers - polyethersulfone (PES) and polyarylate (PAR).The pore size in membrane can be controlled by a blend ratio of PES and PAR. One unique characteristic is that PEPA membrane has three layers of a skin layer on the inner surface, a porous layer in the membrane, and a skin layer on the outer surface, respectively. The permeability of water and substances is controlled by the skin layer on the inner surface. PEPA membrane dialyzer can be adequately considered as a high-performance dialyzer. Furthermore, the skin layer on the outer surface can block endotoxin from the dialysis fluid side. PEPA membrane can therefore be used as an endotoxin-retentive filter. The other unique characteristic is that each amount of albumin loss or β2-microglobulin removal can be controlled by an additive amount of polyvinylpyrrolidone. This means that the PEPA dialyzer can be clinically used to meet the conditions of the patient.
聚酯聚合物合金（PEPA）膜是一种合成聚合物膜。它由两种聚合物组成——聚醚砜（PES）和聚芳酯（PAR）。膜中的孔径可通过PES和PAR的混合比例来控制。一个独特的特点是，PEPA膜分别在内表面有一层皮层、膜内有一层多孔层以及外表面有一层皮层。水和物质的渗透性由内表面的皮层控制。PEPA膜透析器可被充分视为一种高性能透析器。此外，外表面的皮层可阻止透析液侧的内毒素。因此，PEPA膜可用作内毒素保留过滤器。另一个独特的特点是，白蛋白损失量或β2-微球蛋白清除量可通过聚乙烯吡咯烷酮的添加量来控制。这意味着PEPA透析器可在临床上用于满足患者的条件。
