Chan Henry H L
Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong, SAR, China; Wellman Center of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA.
Curr Probl Dermatol. 2011;42:153-159. doi: 10.1159/000328312. Epub 2011 Aug 16.
Today, lasers are being used to treat an increasing number of medical and aesthetic challenges with great success. However, the effects of laser treatments upon darker-skinned patients differ from those on Caucasians in several aspects; this makes their use not without risk. First of all, skin of color has a greater epidermal melanin content than Caucasian skin, and this increase in epidermal pigmentation acts as a competing chromophore. Furthermore, with epidermal melanin acting as a competing chromophore, the light dosage that reaches the actual target is reduced, and higher fluence is necessary to produce a desirable effect. Although effective cooling and longer wavelengths with decreased melanin absorption have been used, the treatment of patients with Fitzpatrick skin types > IV remains associated with a significant risk of side effects. Thus, careful selection of laser and light source parameters in conjunction with skin cooling are important in obtaining desirable clinical outcomes in ethnic skin.
如今,激光正被用于治疗越来越多的医学和美容难题,并取得了巨大成功。然而,激光治疗对肤色较深的患者的影响在几个方面与对白种人的影响有所不同;这使得激光的使用并非毫无风险。首先,有色人种的皮肤表皮黑色素含量高于白种人的皮肤,这种表皮色素沉着的增加起到了竞争发色团的作用。此外,由于表皮黑色素充当竞争发色团,到达实际靶点的光剂量会减少,因此需要更高的能量密度才能产生理想效果。尽管已采用有效的冷却措施以及黑色素吸收减少的更长波长,但对 Fitzpatrick 皮肤类型 > IV 的患者进行治疗仍存在显著的副作用风险。因此,在治疗不同种族皮肤时,结合皮肤冷却仔细选择激光和光源参数对于获得理想的临床效果很重要。