Chadwick Sarah, Heath Rebecca, Shah Mamta
Faculty of Life Sciences, University of Manchester, UK ; Department of Burns and Plastic Surgery, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, UK.
Indian J Plast Surg. 2012 May;45(2):403-11. doi: 10.4103/0970-0358.101328.
Abnormally pigmented scars are an undesirable consequence of cutaneous wound healing and are a complication every single individual worldwide is at risk of. They present a challenge for clinicians, as there are currently no definitive treatment options available, and render scars much more noticeable making them highly distressing for patients. Despite extensive research into both wound healing and the pigment cell, there remains a scarcity of knowledge surrounding the repigmentation of cutaneous scars. Pigment production is complex and under the control of many extrinsic and intrinsic factors and patterns of scar repigmentation are unpredictable. This article gives an overview of human skin pigmentation, repigmentation following wounding and current treatment options.
色素沉着异常的瘢痕是皮肤伤口愈合的不良后果,也是全球每个人都面临的并发症风险。它们给临床医生带来了挑战,因为目前尚无明确的治疗选择,而且会使瘢痕更加明显,给患者带来极大困扰。尽管对伤口愈合和色素细胞都进行了广泛研究,但关于皮肤瘢痕再色素沉着的知识仍然匮乏。色素生成过程复杂,受许多外在和内在因素控制,瘢痕再色素沉着的模式也不可预测。本文概述了人体皮肤色素沉着、伤口愈合后的再色素沉着以及当前的治疗选择。