低剂量三环类抗抑郁药治疗儿童功能性胃肠病的长期疗效。
Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders.
机构信息
Department of Pediatric Gastroenterology and Nutrition, Children's Hospital at Monmouth Medical Center, Long Branch, NJ, USA.
出版信息
J Pediatr Gastroenterol Nutr. 2011 Sep;53(3):260-4. doi: 10.1097/MPG.0b013e318217df7c.
OBJECTIVE
The aim of the study was to determine the long-term efficacy of the tricyclic antidepressant (TCA) drugs amitriptyline or imipramine in treating functional gastrointestinal disorders (FGIDs) in pediatric patients.
MATERIALS AND METHODS
A retrospective chart review of children with a diagnosis of irritable bowel syndrome, functional dyspepsia, and functional abdominal pain diagnosed on the basis of the Rome III criteria was performed. Charts were analyzed for response to the medication and the duration of the response.
RESULTS
A total of 98 patients took a TCA for an FGID. Of the 98 patients, 77 patients (78.6%) responded to the treatment for an average of 10.73 (range 1-45) months.
CONCLUSIONS
TCAs are effective in treating FGIDs in pediatric patients for a long duration.
目的
本研究旨在确定三环类抗抑郁药（TCA）阿米替林或丙咪嗪治疗儿科患者功能性胃肠道疾病（FGIDs）的长期疗效。
材料和方法
对基于 Rome III 标准诊断为肠易激综合征、功能性消化不良和功能性腹痛的儿童进行回顾性图表审查。分析图表以了解对药物的反应和反应持续时间。
结果
共有 98 名患者因 FGID 服用了 TCA。在 98 名患者中，77 名患者（78.6%）对治疗有反应，平均反应持续时间为 10.73 个月（范围为 1-45 个月）。
结论
TCA 治疗儿科患者 FGIDs 的疗效持久。
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