Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA.
Can J Anaesth. 2011 Nov;58(11):986-92. doi: 10.1007/s12630-011-9574-7. Epub 2011 Aug 25.
Hypotension in the sitting position may reduce cerebral perfusion and oxygenation. We prospectively determined the incidence of cerebral oximetry (rSO2) desaturation in seated patients undergoing ambulatory shoulder arthroscopy.
A cohort of 99 patients received regional anesthesia and intravenous sedation, and their blood pressure was recorded every five minutes. Hypotension was defined as the occurrence of any of the following: > 30% decline in mean arterial pressure (MAP), systolic blood pressure < 90 mmHg, or MAP <66 mmHg. Cerebral desaturation was defined as a > 20% decrease in rSO2 from baseline. The association of rSO2 desaturation with potential risk factors was examined by the generalized estimating equation to account for within patient correlation and multiple observations per patient. We fitted desaturation with three models: 1) unadjusted (i.e., hypotension as sole regressor); 2) time-trend adjusted; and 3) baseline-factors adjusted model.
Hypotension occurred in 76% of observations (mean duration 4,261 sec), but cerebral desaturation was seen in only 0.77% of observations (mean duration 426 sec). Ninety-nine percent of patients experienced hypotension, but cerebral desaturation occurred in only 10%. By unadjusted modelling, hypotension was associated with cerebral desaturation (odds ratio = 3.21; P = 0.02). Once time-trend adjusted, cerebral desaturation was associated with time from baseline but not with hypotension (P = 0.14). When adjusted for baseline factors, the analysis demonstrated a non-significant association with hypotension (P = 0.34) but a significant association with the presence of risk factors for cerebrovascular disease (P = 0.01).
Despite frequent hypotension in the sitting position, rSO2 desaturation was uncommon during shoulder arthroscopy performed in the sitting position with regional anesthesia.
坐姿时的低血压可能会降低脑灌注和氧合。我们前瞻性地确定了在接受门诊肩部关节镜检查的坐姿患者中脑氧饱和度(rSO2)饱和度降低的发生率。
一组 99 名患者接受区域麻醉和静脉镇静,每 5 分钟记录一次血压。低血压定义为出现以下任何一种情况:平均动脉压(MAP)下降> 30%、收缩压< 90mmHg 或 MAP<66mmHg。脑饱和度降低定义为 rSO2 从基线下降> 20%。使用广义估计方程检查 rSO2 饱和度降低与潜在危险因素之间的关联,以考虑到患者内相关性和每个患者的多次观察。我们使用三个模型拟合饱和度降低:1)未调整(即,低血压作为唯一回归量);2)时间趋势调整;3)基线因素调整模型。
观察到 76%的观察出现低血压(平均持续时间 4261 秒),但仅 0.77%的观察出现脑饱和度降低(平均持续时间 426 秒)。99%的患者出现低血压,但只有 10%出现脑饱和度降低。通过未调整的模型,低血压与脑饱和度降低相关(优势比=3.21;P=0.02)。一旦进行时间趋势调整,脑饱和度降低与从基线开始的时间相关,但与低血压无关(P=0.14)。当调整基线因素时,分析显示与低血压无显著关联(P=0.34),但与脑血管疾病危险因素存在显著关联(P=0.01)。
尽管在坐姿时经常出现低血压,但在接受区域麻醉的坐姿肩部关节镜检查中,rSO2 饱和度降低并不常见。