Romanowicz-Makowska Hanna, Smolarz Beata, Houli Amer, Szyłło Krzysztof
Department of Pathology, Institute of Polish Mother's Memorial Hospital, Łódź, Poland.
Pol J Pathol. 2011;62(2):89-94.
Polymorphisms in the human oxoguanine glycosylase 1 ( hOGG1 ) and X-ray repair cross-complementing 1 ( XRCC1 ) genes have been extensively studied in the association with various human cancers such as endometrial cancer.
The genotype analysis of hOGG1 Ser326Cys and XRCC1 Arg399Gln gene polymorphisms for 150 endometrial cancer patients and 150 controls of cancer-free subjects, in the Polish population, were performed using PCR-based restriction fragment length polymorphism (PCR-RFLP).
Although there were no significant (p > 0.05) differences in the frequencies of genotypes or alleles of hOGG1 genes between patients and controls, the frequency of the XRCC1 399Gln allele was significantly greater in endometrial cancer patients compared with controls (p = 0.033) with an odds ratio of 1.39 (95% confidence interval 0.99 to 1.95). The distributions of genotypes and alleles of the genes hOGG1 and XRCC1 were not significantly associated with different grades of endometrial cancer (p > 0.05).
In conclusion, these findings indicated that XRCC1 Arg399Gln polymorphism may be a genetic determinant for developing endometrial cancer. The hOGG1 Ser326Cys may not play an important role in susceptibility to endometrial cancer in Polish women.
人类氧鸟嘌呤糖基化酶1（hOGG1）和X射线修复交叉互补蛋白1（XRCC1）基因的多态性与子宫内膜癌等多种人类癌症的关联已得到广泛研究。
采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）方法，对波兰人群中150例子宫内膜癌患者和150例无癌对照者的hOGG1 Ser326Cys和XRCC1 Arg399Gln基因多态性进行基因分型分析。
尽管患者与对照之间hOGG1基因的基因型或等位基因频率无显著差异（p>0.05），但子宫内膜癌患者中XRCC1 399Gln等位基因的频率显著高于对照（p = 0.033），优势比为1.39（95%置信区间0.99至1.95）。hOGG1和XRCC1基因的基因型和等位基因分布与不同分级的子宫内膜癌无显著关联（p>0.05）。
总之，这些发现表明XRCC1 Arg399Gln多态性可能是子宫内膜癌发生的遗传决定因素。hOGG1 Ser326Cys可能在波兰女性子宫内膜癌易感性中不发挥重要作用。
