[通过MRI化学位移成像测量健康男性的胰腺脂肪分数]
[Pancreatic fat fraction in healthy men measured with MRI chemical shift imaging].
作者信息
Xie Yi, Li Jing, Yuan Fang, Tang Cheng-Wei
机构信息
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):527-30.
OBJECTIVE
To detect the range of pancreatic fat fraction in healthy men, and the distribution of fat in pancreas.
METHODS
A calibration curve was established by standard fat-water mixture model. Then, 83 healthy men were selected randomly. The participants were divided into three groups by age: group A 20-30 years (29 cases), group B 31-40 years (27 cases), group C 41-50 years (27 cases). The fat content in pancreas of the participants were quantified with double-echo chemical shift gradient-echo MR.
RESULTS
A perfect correlation between the MRI measurements and the true value of fat-water mixture was found (r = 0.996, P<0.01). There was no significant difference in the fat content of 3 different pancreatic regions (P>0.05). The 95% confidence interval of fat fraction ranged from 1.25%-4.83%, 1.58%-4.35%, 1.41%-4.75%, and 1.87%-4.19% in pancreatic head, body,nail and whole pancreas, respectively. No significant differences were found between the age groups (P>0.05).
CONCLUSION
Chemical-shift MR imaging is a reliable and safe noninvasive technique for the detection and quantification of fat. It can be useful in quantifying the fat fraction of pancreas. The fat content in healthy men of 20-50 years does not vary with age and in different pancreatic regions.
目的
检测健康男性胰腺脂肪分数范围及胰腺内脂肪分布情况。
方法
采用标准脂肪-水混合模型建立校准曲线。随机选取83名健康男性，按年龄分为三组：A组20 - 30岁（29例），B组31 - 40岁（27例），C组41 - 50岁（27例）。采用双回波化学位移梯度回波磁共振成像对参与者胰腺内脂肪含量进行定量分析。
结果
磁共振成像测量值与脂肪-水混合模型真实值之间存在良好相关性（r = 0.996，P<0.01）。胰腺三个不同区域的脂肪含量无显著差异（P>0.05）。胰头、胰体、胰尾及全胰腺的脂肪分数95%置信区间分别为1.25% - 4.83%、1.58% - 4.35%、1.41% - 4.75%和1.87% - 4.19%。各年龄组之间无显著差异（P>0.05）。
结论
化学位移磁共振成像技术是一种可靠、安全的无创脂肪检测与定量分析技术，可用于胰腺脂肪分数的定量分析。20 - 50岁健康男性的胰腺脂肪含量在不同年龄及不同胰腺区域无差异。
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