Shan Meng-jun, Han Bao-hui, You Jie
The Third Department of Tumor, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Jul;31(7):873-9.
To assess the therapeutic efficacy of treating advanced non-small cell lung cancer (NSCLC) in the aged by Chinese medicine (CM) adopting the international questionnaire of quality of life (QOL).
91 aged patients with advanced NSCLC were randomly assigned to three groups. There were 31 in the CM group (Group I), 30 in the chemotherapy group (Group II), and 30 in the CM and chemotherapy combination group (Group III). Oral administration of CM decoction and intravenous dripping of Chinese patent medicine was given to those in Group I. Patients in Group II received chemotherapeutic protocol alone. Patients in Group III received chemotherapeutic protocol while orally taking CM decoction. Twenty-eight days were taken as one therapeutic course, and two courses in total. Assessment was performed using European Organization for Research and Treatment of Lung Cancer Quality of Life Questionnaire LC-43 (EORTC QLQ-LC43) before treatment, the 10th day of the second therapeutic course, and the 28th day of the second therapeutic course, respectively.
After two therapeutic courses of treatment, compared with Group II, better effects were obtained in Group I and Group III in the aspects of the physical function, roles function, emotional functions, social functions, general health state, and short breath, cough, fatigue, insomnia, poor appetite, and constipation (P<0.05, P<0.01).
CM therapy could relieve the clinical symptoms of aged patients with advanced NSCLC and improve their QOL.
采用国际生活质量问卷评估中医药治疗老年晚期非小细胞肺癌（NSCLC）的疗效。
将91例老年晚期NSCLC患者随机分为三组。中药组（I组）31例，化疗组（II组）30例，中药联合化疗组（III组）30例。I组患者口服中药汤剂并静脉滴注中成药。II组患者仅接受化疗方案。III组患者在接受化疗方案的同时口服中药汤剂。以28天为一个疗程，共两个疗程。分别在治疗前、第二个疗程的第10天和第二个疗程的第28天，使用欧洲癌症研究与治疗组织肺癌生活质量问卷LC-43（EORTC QLQ-LC43）进行评估。
经过两个疗程的治疗后，与II组相比，I组和III组在身体功能、角色功能、情感功能、社会功能、总体健康状况以及气短、咳嗽、疲劳、失眠、食欲不振和便秘等方面均取得了更好的效果（P<0.05，P<0.01）。
中医药治疗可缓解老年晚期NSCLC患者的临床症状，提高其生活质量。
