Yuan Lin, Zhang Pei-tong, Yang Zong-yan
Department of Tumor, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Jul;31(7):880-3.
To study the qi deficiency syndrome distribution and quality of life (QOL) of patients with advanced non-small cell lung cancer (NSCLC).
A questionnaire survey was conducted in 120 patients with advanced NSCLC using the QOL scale "Functional Assessment of Cancer Therapy" (FACT-L) (Version 4.0). Meanwhile, syndrome typing was performed. On the basis of results of syndrome typing, patients of different syndrome types were grouped and compared, thus studying the distribution of advanced NSCLC patients of qi deficiency syndrome and qi deficiency syndrome correlated QOL features.
Qi deficiency, blood stasis, yin deficiency, phlegm and dampness dominated in syndrome types of the 120 patients with advanced NSCLC. Of syndrome types accounting for larger ratios in 112 patients, pure qi deficiency syndrome accounted for 30.36% (34 cases), qi deficiency and blood stasis syndrome for 18. 75% (21 cases), both qi and yin deficiency syndrome for 10. 71% (12 cases). There was no correlation between the appearance of qi deficiency syndrome and patients' age, sex, pathological typing (adenocarcinoma/squamous carcinoma), or the disease duration. NSCLC patients in phase IV were mostly complicated with qi deficiency syndrome (P<0.05). Scores of physical states, emotional states, functional states, and total scores in the FACT-L scale were lower in those complicated with qi deficiency syndrome (89 cases) than in those without complicated qi deficiency syndrome (31 cases), showing statistical difference (P<0.01, P<0.05). The scores of the lung cancer specific module (additional concerns) in the FACT-L scale showed statistical difference, sequenced as qi deficiency and blood stasis syndrome > pure qi deficiency syndrome > both qi and yin deficiency syndrome (P<0.05).
Qi deficiency syndrome is the main syndrome of advanced NSCLC. The QOL of advanced NSCLC patients complicated with qi deficiency syndrome was poorer than those without complicated qi deficiency syndrome. Besides, along with the aggravation of qi deficiency syndrome, the QOL decreased somewhat. It suggested that symptomatic treatment of qi deficiency syndrome could improve advanced NSCLC patients' QOL.
研究晚期非小细胞肺癌（NSCLC）患者的气虚证分布及生活质量（QOL）。
采用“癌症治疗功能评价”（FACT-L）量表（第4.0版）对120例晚期NSCLC患者进行问卷调查。同时进行辨证分型。根据辨证分型结果，对不同证型患者进行分组比较，从而研究晚期NSCLC患者气虚证的分布及与气虚证相关的生活质量特征。
120例晚期NSCLC患者的证型以气虚、血瘀、阴虚、痰湿为主。在112例占比相对较大的证型中，单纯气虚证占30.36%（34例），气虚血瘀证占18.75%（21例），气阴两虚证占10.71%（12例）。气虚证的出现与患者年龄、性别、病理分型（腺癌/鳞癌）或病程均无相关性。Ⅳ期NSCLC患者大多合并气虚证（P<0.05）。合并气虚证的89例患者在FACT-L量表中的生理状态、情感状态、功能状态及总分均低于未合并气虚证的31例患者，差异有统计学意义（P<0.01，P<0.05）。FACT-L量表中肺癌特异性模块（附加关注）的得分差异有统计学意义，顺序为气虚血瘀证>单纯气虚证>气阴两虚证（P<0.05）。
气虚证是晚期NSCLC的主要证型。合并气虚证的晚期NSCLC患者生活质量较未合并者差。此外，随着气虚证的加重，生活质量有所下降。提示对气虚证进行对症治疗可改善晚期NSCLC患者的生活质量。
