Wang Juan, Chen Chan, Zhao Hui-Hui, Chen Jian-Xin, Luo Liang-Tao, Xu Xue-Gong, Gao Shan-Shan, Zhang Li, Wang Wei
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Feb;34(2):141-5.
To study the correlation between various complications of chronic heart failure (CHF) patients and Chinese medical syndromes, thus indicating distribution laws of Chinese medical syndromes in various complications of CHF patients.
Chinese medical syndrome typing was performed in 630 CHF patients by cross-sectional study of the demographic data, history of present diseases, related information on Chinese medical four diagnostic methods, and the distribution of complications. Logistic regression analysis was used to determine the correlation of various complications of CHF patients and Chinese medical syndromes.
In this study, recruited were common complications such as hypertension, diabetes, arrhythmia, hyperlipemia, and cerebral vascular accident, and so on. Main syndromes were sequenced as qi deficiency syndrome, blood stasis syndrome, water retention syndrome, yin deficiency syndrome, phlegm turbid syndrome, yang deficiency syndrome. Results of Logistic regression analysis indicated that correlation existed between common complications and Chinese medical syndromes. In CHF complicated hypertension patients, Logistic regression analysis showed qi deficiency syndrome and yang deficiency syndrome were negatively correlated with hypertension (P < 0.05). In CHF complicated diabetes patients, Logistic regression analysis showed phlegm turbid syndrome and water retention syndrome were positively correlated with diabetes (P < 0.05). In CHF complicated arrhythmia patients, there was no statistical difference in the distribution of each syndrome (P > 0.05). In CHF complicated hyperlipemia patients, Logistic regression analysis showed qi deficiency syndrome and water retention syndrome were negatively correlated with hyperlipemia (P < 0.05), while blood stasis syndrome, yin deficiency syndrome, and phlegm turbid syndrome were positively correlated with hyperlipemia (P < 0.01). In CHF complicated cerebral vascular accident patients, Logistic regression analysis showed qi deficiency syndrome and yang deficiency syndrome were negatively correlated with cerebral vascular accident (P < 0.01, P < 0.05).
There existed certain correlations between complications of CHF and the distribution of main Chinese medical syndromes. It could be used as guidance for treating CHF and its various complications by Chinese medicine and pharmacy.
研究慢性心力衰竭（CHF）患者各种并发症与中医证候的相关性，以揭示CHF患者各种并发症中中医证候的分布规律。
采用横断面研究方法，对630例CHF患者进行人口学资料、现病史、中医四诊相关信息及并发症分布情况的调查，并进行中医证候分型。采用Logistic回归分析确定CHF患者各种并发症与中医证候的相关性。
本研究纳入的常见并发症有高血压、糖尿病、心律失常、高脂血症、脑血管意外等。主要证候依次为气虚证、血瘀证、水饮证、阴虚证、痰浊证、阳虚证。Logistic回归分析结果表明，常见并发症与中医证候之间存在相关性。在CHF合并高血压患者中，Logistic回归分析显示气虚证和阳虚证与高血压呈负相关（P<0.05）。在CHF合并糖尿病患者中，Logistic回归分析显示痰浊证和水饮证与糖尿病呈正相关（P<0.05）。在CHF合并心律失常患者中，各证候分布无统计学差异（P>0.05）。在CHF合并高脂血症患者中，Logistic回归分析显示气虚证和水饮证与高脂血症呈负相关（P<0.05），而血瘀证、阴虚证和痰浊证与高脂血症呈正相关（P<0.01）。在CHF合并脑血管意外患者中，Logistic回归分析显示气虚证和阳虚证与脑血管意外呈负相关（P<0.01，P<0.05）。
CHF并发症与主要中医证候分布之间存在一定相关性，可为中医药治疗CHF及其各种并发症提供指导。
