An Zhi-Ming, Zhai Yong-Ping
Department of Hematology, Nanjing General Hospital, Nanjing Military Area, Nanjing, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):1087-91.
Hypereosinophilic syndromes (HES) are a heterogeneous group of uncommon disorders which characterized by marked peripheral eosinophilia and function damage of target organ, with different etiologies, mechanisms and therapies in different subtypes. Formerly the prognosis was very poor, nowadays with great development in science and medicine, we can understand HES much better in classification, diagnosis and therapy, including the development of novel targeted therapies, such as tyrosine kinase inhibitors and humanized monoclonal antibodies, which increased the treatment selection and complexity of therapeutic decisions in HES. This review discusses the classification of HES and characters of different subtypes, including therapeutic methods, which can help clinical doctors to have a good understanding of HES.
高嗜酸性粒细胞综合征（HES）是一组异质性的罕见疾病，其特征为外周血嗜酸性粒细胞显著增多以及靶器官功能损害，不同亚型具有不同的病因、发病机制和治疗方法。以前其预后很差，如今随着科学和医学的巨大发展，我们在HES的分类、诊断和治疗方面有了更深入的了解，包括新型靶向治疗的发展，如酪氨酸激酶抑制剂和人源化单克隆抗体，这增加了HES的治疗选择和治疗决策的复杂性。本文综述了HES的分类以及不同亚型特征，包括治疗方法，有助于临床医生更好地了解HES。
