Leyden J J
University of Pennsylvania School of Medicine, Philadelphia 19104.
Br J Dermatol. 1990 Apr;122 Suppl 35:83-6. doi: 10.1111/j.1365-2133.1990.tb16130.x.
Tretinoin was shown in the late 1960s to be useful for the treatment of disorders associated with abnormal epithelial differentiation; however, because of irritation, retinoids were only slowly accepted. In the 1970s, evidence accumulated to show that topical tretinoin could modulate many of the abnormalities in the epidermis and dermis associated with photoageing. It has been shown in hairless mice that tretinoin can reverse dermal elastosis with the formation of new collagen and this has led to clinical trials being carried out in man. Randomized, controlled trials have shown that topical tretinoin is effective in the treatment of photoaged skin.
20世纪60年代末，维甲酸被证明可用于治疗与上皮异常分化相关的疾病；然而，由于有刺激性，类维生素A仅被缓慢接受。20世纪70年代，越来越多的证据表明局部使用维甲酸可以调节与光老化相关的表皮和真皮中的许多异常情况。在无毛小鼠身上已证实，维甲酸可通过形成新的胶原蛋白来逆转皮肤弹性组织变性，这也促使在人体上开展了临床试验。随机对照试验表明，局部使用维甲酸对治疗光老化皮肤有效。
