Gynecologic Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Fertil Steril. 2011 Oct;96(4):974-9. doi: 10.1016/j.fertnstert.2011.07.1148. Epub 2011 Aug 24.
To test the association between polymorphisms rs9939609 T>A and rs8050136 A>C of the fat mass and obesity-associated (FTO) gene and metabolic and cardiovascular variables in postmenopause.
Cross-sectional study.
University hospital.
PATIENT(S): A total of 135 postmenopausal women (mean age 52 ± 4 years).
INTERVENTION(S): Anthropometric measurements and collection of blood samples.
MAIN OUTCOME MEASURE(S): Blood pressure, metabolic variables, and FTO genotype.
RESULT(S): The frequency of polymorphism rs9939609 was 43.7% for the wild TT genotype, 43.0% for TA, and 13.3% for AA. The frequency of the rs8050136 polymorphism was 12.6% for the wild AA genotype, 39.3% for AC, and 48.1% for CC. The polymorphic AA genotype of the SNP rs9939609 was associated with higher glucose levels and lipid accumulation product (LAP) index, whereas the wild AA genotype of the SNP rs8050136 was associated with higher LAP.
CONCLUSION(S): The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause. Further studies are needed in different ethnic backgrounds to confirm the clinical relevance of these associations.
检测脂肪量和肥胖相关基因（FTO）rs9939609T>A 和 rs8050136A>C 多态性与绝经后代谢和心血管变量之间的关联。
横断面研究。
大学医院。
共 135 名绝经后妇女（平均年龄 52±4 岁）。
体格测量和采血。
血压、代谢变量和 FTO 基因型。
rs9939609 多态性的野生 TT 基因型频率为 43.7%，TA 基因型为 43.0%，AA 基因型为 13.3%。rs8050136 多态性的野生 AA 基因型频率为 12.6%，AC 基因型为 39.3%，CC 基因型为 48.1%。SNP rs9939609 的 AA 基因型与较高的血糖水平和脂质蓄积产物（LAP）指数相关，而 SNP rs8050136 的野生 AA 基因型与较高的 LAP 相关。
FTO 基因的 rs9939609 多态性与异常血糖水平以及绝经后糖尿病和心血管风险的替代标志物 LAP 相关。需要在不同的种族背景下进行进一步的研究，以确认这些关联的临床意义。
