Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
J Clin Neurosci. 2011 Nov;18(11):1554-5. doi: 10.1016/j.jocn.2011.04.003. Epub 2011 Aug 24.
We report a now 74-year-old patient who was successfully treated with a methotrexate (MTX)-ssbased polychemotherapy protocol (Bonn protocol) for primary central nervous system lymphoma (PCNSL) in 1996. When presenting with an unusually late relapse after 13 years of tumor-free survival the diagnosis was made on the basis of clinical and radiological criteria. In the context of the very limited treatment options for recurrent PCNSL, it is reassuring that the re-application of high dose-MTX-based polychemotherapy, including intraventricular treatment, again succeeded in a sustained complete response with still low neurotoxicity.
我们报告了一位现年 74 岁的患者，他于 1996 年成功接受了甲氨蝶呤（MTX）-ss 为基础的联合化疗方案（波恩方案）治疗原发性中枢神经系统淋巴瘤（PCNSL）。13 年无肿瘤生存后，他出现了异常迟发复发，根据临床和影像学标准做出了诊断。在复发 PCNSL 的治疗选择非常有限的情况下，令人欣慰的是，再次应用大剂量 MTX 为基础的联合化疗，包括脑室内治疗，再次成功地获得了持续完全缓解，并且神经毒性仍然较低。
