Li Pengchao, Song Ninghong, Yin Changjun, Zhang Wei, Li Jie, Hua Lixin, Wang Zengjun, Cheng Gong
Department of Urology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
J Androl. 2012 May-Jun;33(3):435-40. doi: 10.2164/jandrol.111.013896. Epub 2011 Aug 25.
In this study, we investigated the safety and feasibility of glans-preserving surgery for superficial penile squamous cell carcinoma. Young patients with penile primary tumors exhibiting favorable histologic features were best suited for organ-sparing procedures, enabling them to avoid sexual disturbances. The study included 12 patients, 38-53 years of age (median age 46 years), with superficial lesions involving the glans penis, coronary sulcus, or shaft skin. After clinical staging and grading, those patients were offered a glans-preserving procedure to preserve the normal appearance and functional integrity of the glans penis. Of the 12 patients referred, the tumors were TaG1 in 4 patients, TaG2 in 3, TisG1 in 1, TisG2 in 1, T1G1 in 2, and T1G2 in 1. All patients returned to normal sexual activity 1 month postoperatively. Sexual function and sexual satisfaction were well maintained after surgery. The cosmetic results were considered satisfying/very satisfying by 83% (10 of 12 patients). Follow-up data were available on 12 patients at a mean follow-up of 62.5 months. Only 1 patient had recurrence 6 months after surgery, which was managed by a second glans-preserving surgery without recurrence. With careful patient selection and vigilant follow-up, anatomically suitable superficial penile cancer can be offered this glans-preserving surgery, while preserving function of the penis wherever possible.
在本研究中,我们调查了保留龟头手术治疗浅表性阴茎鳞状细胞癌的安全性和可行性。阴茎原发性肿瘤具有良好组织学特征的年轻患者最适合保留器官的手术,这能使他们避免性功能障碍。该研究纳入了12例年龄在38至53岁(中位年龄46岁)之间的患者,浅表病变累及阴茎头、冠状沟或阴茎体皮肤。经临床分期和分级后,为这些患者提供了保留龟头的手术,以保持阴茎头的正常外观和功能完整性。在转诊的12例患者中,4例为TaG1期肿瘤,3例为TaG2期,1例为TisG1期,1例为TisG2期,2例为T1G1期,1例为T1G2期。所有患者术后1个月恢复正常性生活。术后性功能和性满意度得到良好维持。83%(12例中的10例)的患者认为美容效果令人满意/非常满意。12例患者均有随访数据,平均随访时间为62.5个月。仅1例患者术后6个月复发,通过再次保留龟头手术治疗后未复发。通过仔细选择患者和进行密切随访,对于解剖学上合适的浅表性阴茎癌患者,可以提供这种保留龟头的手术,同时尽可能保留阴茎功能。