Department of Urology, Sunderland Royal Hospital, UK.
BJU Int. 2012 Dec;110(11):1792-5. doi: 10.1111/j.1464-410X.2012.11084.x. Epub 2012 May 2.
Study Type--Therapy (case series) Level of Evidence 4. What's known on the subject? and What does the study add? Organ-preserving surgeries for penile cancer have been described to reduce the morbidity associated with traditional operations. Patients derive better functional outcomes from penile-preserving surgery, although local recurrence rates can be higher. Excellent results can be obtained at large-volume centres. With close follow-up, local recurrences can be identified and treated promptly (often with further local excision).
• To describe the outcomes of organ-preserving surgery for penile cancer at a UK tertiary referral centre.
• Patients at Sunderland Hospital (UK) between 2001 and 2008 who had squamous cell tumours limited to the glans penis underwent penile-preserving surgery including total glansectomy and glanuloplasty, partial glansectomy, glans relining and distal penectomy with glans reconstruction. • Recurrence rates, cosmetic and functional outcomes were recorded.
• In all, 65 patients were identified with a median follow-up of 40 months. Local recurrence was present in four patients (6%) despite 72% having intermediate or poorly differentiated tumours and 30% with T2 disease. • Complications included partial graft loss (1.5%), graft contractures (4.5%) and meatal stenosis (7.5%). • In all, 5% were deemed to have poor cosmetic outcome and 85% described good erections at 1 year after surgery.
• Penile-preserving surgery can achieve good penile cancer control with minimal morbidity and reduced psychosexual side-effects.
描述英国一家三级转诊中心行保留器官手术治疗阴茎癌的结果。
2001 年至 2008 年间，桑德兰医院（英国）的阴茎局限于龟头的鳞状细胞肿瘤患者接受保留器官手术，包括全龟头切除术和龟头成形术、部分龟头切除术、龟头衬里术和远端阴茎切除术加龟头重建术。
共发现 65 例患者，中位随访时间为 40 个月。尽管 72%的肿瘤为中分化或低分化，30%的患者为 T2 期，但仍有 4 例（6%）患者出现局部复发。
并发症包括部分移植物丢失（1.5%）、移植物挛缩（4.5%）和尿道口狭窄（7.5%）。
所有患者中，5%的人认为美容效果差，85%的人在手术后 1 年描述勃起良好。
保留器官手术可以在最小的发病率和减少心理性副作用的情况下实现良好的阴茎癌控制。
