Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA.
J Perinatol. 2012 Jun;32(6):448-53. doi: 10.1038/jp.2011.121. Epub 2011 Aug 25.
Head ultrasonography (HUS) is a reliable and easy to perform bedside imaging technique that can give valuable information about degree of brain injury/edema after perinatal asphyxia in term neonates. The goals of our study were to determine whether semiquantitative markers such as standardized white matter/gray matter (WM/GM) echogenicity ratio and resistive index (RI) value measured by HUS differs between asphyxiated term neonates and healthy controls.
Thirty-one carefully selected term neonates who suffered from perinatal hypoxic-ischemic encephalopathy (HIE) were included in the study. The ratio of the WM/GM echogenicity of the cingulate gyrus was calculated. In addition, the RI value was measured in the anterior cerebral artery. US scalars were compared with 11 healthy neonates.
WM/GM ratio is significantly increased and RI value significantly decreased in asphyxiated term neonates compared with healthy subjects.
WM/GM ratio and RI value allows discriminating between asphyxiated neonates and healthy subjects. These US scalars may serve as valuable, easy to acquire semiquantitative bedside markers of brain HIE, when magnetic resonance imaging is unavailable or cannot be performed in the acute setting.
头超声（HUS）是一种可靠且易于进行的床边成像技术，可提供有关足月新生儿围产期窒息后脑损伤/水肿程度的有价值信息。我们研究的目的是确定 HUS 测量的半定量标志物（如标准化的白质/灰质（WM/GM）回声强度比和阻力指数（RI）值）是否在窒息的足月新生儿和健康对照组之间存在差异。
本研究纳入了 31 名精心挑选的患有围产期缺氧缺血性脑病（HIE）的足月新生儿。计算了扣带回白质/灰质回声强度比。此外，在前大脑动脉中测量了 RI 值。将 US 标测值与 11 名健康新生儿进行比较。
与健康受试者相比，窒息的足月新生儿的 WM/GM 比值显著增加，RI 值显著降低。
WM/GM 比值和 RI 值可区分窒息的新生儿和健康受试者。当磁共振成像不可用或无法在急性期进行时，这些 US 标测值可能成为有价值的、易于获取的脑 HIE 半定量床边标志物。
