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WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse: successful maintenance of durable remission.

作者信息

Hashii Y, Sato-Miyashita E, Matsumura R, Kusuki S, Yoshida H, Ohta H, Hosen N, Tsuboi A, Oji Y, Oka Y, Sugiyama H, Ozono K

出版信息

Leukemia. 2012 Mar;26(3):530-2. doi: 10.1038/leu.2011.226. Epub 2011 Aug 26.

DOI:10.1038/leu.2011.226
PMID:21869838
Abstract
摘要

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WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse: successful maintenance of durable remission.WT1肽疫苗接种用于复发高危的小儿白血病患者异基因干细胞移植后：成功维持持久缓解
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WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation.从健康供体外周血中产生的WT1肽特异性T细胞：对异基因干细胞移植后过继性免疫治疗的潜在意义。
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WT1-specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation.在非清髓性移植后不久即获得完全供者嵌合体的患者的外周血中，可能存在受者来源的 WT1 特异性 CTL 细胞。
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Potential of dendritic-cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide- and keyhole-limpet-hemocyanin-pulsed, donor-derived dendritic-cell vaccine for acute myeloid leukemia.WT1肽和钥孔戚血蓝蛋白脉冲处理的供体来源树突状细胞疫苗用于急性髓系白血病，显示了异基因造血干细胞移植后树突状细胞免疫疗法对复发的治疗潜力。
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Standard versus alternative myeloablative conditioning regimens in allogeneic hematopoietic stem cell transplantation for high-risk acute leukemia.高危急性白血病异基因造血干细胞移植中标准与替代清髓性预处理方案的比较
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[Immunotherapy for leukemia cells by using cytotoxic T lymphocyte specifically against WT1-derived peptide: an experimental study in vitro].[利用特异性针对WT1衍生肽的细胞毒性T淋巴细胞对白血病细胞进行免疫治疗：体外实验研究]
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