Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Chem Commun (Camb). 2011 Oct 14;47(38):10611-3. doi: 10.1039/c1cc14257g. Epub 2011 Aug 25.
Heck reactions were performed on α,β-unsaturated-δ-sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the β position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines.
进行了 Heck 反应于 α,β-不饱和-δ-磺酰胺中间体，由交叉复分解反应得到，以允许在β位引入取代基。随后的一锅法环化/消除提供了一种操作简单、催化和收敛的 2,4,6-三取代吡啶合成方法。
