[儿童对蛔虫的致敏作用与哮喘严重程度]
[Sensitization to ascaris lumbricoides and asthma severity in children].
作者信息
Rîpă Carmen, Bahnea Roxana-Gabriela, Cojocaru Ingrid, Luca Mihaela Cătălina, Leon Maria, Luca Mariana
机构信息
Universităţii de Medicină şi Farmacie Gr. T. Popa Iaşi, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2011 Apr-Jun;115(2):387-91.
UNLABELLED
There is little information concerning asthma severity and sensitization to Ascaris lumbricoides in pediatric patients.
MATERIAL AND METHODS
The relationship between sensitization to Ascaris lumbricoides and asthma severity in 219 patients with a high prevalence of parasitic exposure (IgE antibodies) was studied by using linear, multivariate and logistic regression.
RESULTS
Sensitization to Ascaris lumbricoides was associated with positive skin tests for aeroallergens, increased total serum IgE, increased eosinophils, reductions in FEV1 and FEV1/FVC ratio, increased airway Methacholine, bronchodilator responsiveness, and hospitalizations for asthma in the past year.
CONCLUSIONS
Sensitization to Ascaris lumbricoides is associated with increased severity of asthma among Romanian children. This association is mediated by a high degree of atopy among the asthma children sensitized to Ascaris lumbricoides and belonging to a population with a low prevalence of helminthiasis.
未标记
关于儿科患者哮喘严重程度和对蛔虫致敏的信息很少。
材料与方法
采用线性、多变量和逻辑回归研究了219名寄生虫暴露（IgE抗体）患病率高的患者对蛔虫的致敏与哮喘严重程度之间的关系。
结果
对蛔虫的致敏与气传变应原皮肤试验阳性、血清总IgE增加、嗜酸性粒细胞增多、第一秒用力呼气容积（FEV1）和FEV1/用力肺活量（FVC）比值降低、气道对乙酰甲胆碱反应性增加、支气管扩张剂反应性增加以及过去一年因哮喘住院有关。
结论
对蛔虫的致敏与罗马尼亚儿童哮喘严重程度增加有关。这种关联是由对蛔虫致敏且属于蠕虫病患病率低的人群中的哮喘儿童的高度特应性介导的。
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