Departamento de Ciencias del Medio Natural, Universidad Pública de Navarra, Campus Arrosadia, E-31006 Pamplona, Spain.
J Agric Food Chem. 2011 Sep 28;59(18):10162-8. doi: 10.1021/jf2025538. Epub 2011 Sep 2.
Chlorsulfuron and imazethapyr (herbicides that inhibit acetolactate synthase; ALS, EC 4.1.3.18) produced a strong accumulation of hydroxycinnamic acids that was related to the induction of the first enzyme of the shikimate pathway, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (EC 2.5.2.54). The exogenous application of two hydroxycinnamic acids, ferulic and p-coumaric acids, to pea plants resulted in their internal accumulation, arrested growth, carbohydrate and quinate accumulation in the leaves, and the induction of ethanolic fermentation. These effects resemble some of the physiological effects detected after acetolactate synthase inhibition and suggest important roles for ferulic and p-coumaric acids in the mode of action of herbicides inhibiting the biosynthesis of branched chain amino acids.
氯磺隆和咪草烟（抑制乙酰乳酸合酶的除草剂；ALS，EC4.1.3.18）导致羟基肉桂酸强烈积累，这与分支氨基酸生物合成抑制剂中第一个酶，即 3-脱氧-D-阿拉伯庚酮糖-7-磷酸合酶（EC2.5.2.54）的诱导有关。两种羟基肉桂酸，阿魏酸和对香豆酸，被施用于豌豆植物后会在植物体内积累，从而导致植物生长停止、叶片中碳水化合物和奎宁酸积累，并诱导出乙醇发酵。这些效应类似于在乙酰乳酸合酶抑制后检测到的一些生理效应，这表明阿魏酸和对香豆酸在抑制支链氨基酸生物合成的除草剂作用模式中具有重要作用。
