Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, 463-707, South Korea.
Metabolism. 2012 Mar;61(3):317-24. doi: 10.1016/j.metabol.2011.07.005. Epub 2011 Aug 25.
The objective of the study was to investigate the association between metabolic syndrome (MS) and muscle strength in community-dwelling older men and women in Korea. Korean men and women 65 years and older living in a single, typical South Korean city (n = 647) were enrolled in the Korean Longitudinal Study on Health and Aging study. The diagnosis of MS was evaluated according to the definition of the National Cholesterol Education Program Adult Treatment Panel III. Isokinetic muscle strength of the knee extensors, as determined by peak torque per body weight (newton meter per kilogram) and hand-grip strength per body weight (newton per kilogram), was measured. Participants without MS had greater leg muscle strength and grip strength per weight. The effect of MS on muscle strength was more prominent in men than in women in our study population. Only men showed a significant interaction between MS and age for muscle strength (P = .014), and the effect was greater in men aged 65 to 74 years compared with those older than 75 years (119.2 ± 31.2 vs 134.5 ± 24.3 N m/kg). Participants with MS had weaker knee extensor strength after controlling the covariates (β = -90.80, P = .003), and the interaction term (age × MS × male sex) was significant (β = 1.00, P = .017). Metabolic syndrome is associated with muscle weakness, and this relationship is particularly pronounced in men. Age can modify the impact of MS on muscle strength. Men aged 65 to 74 years with MS need a thorough assessment of muscle strength to prevent disability.
本研究旨在探讨代谢综合征（MS）与社区居住的韩国老年男性和女性肌肉力量之间的关系。韩国年龄在 65 岁及以上、居住在一个典型的韩国城市中的男性和女性（n=647）参加了韩国健康老龄化纵向研究。根据国家胆固醇教育计划成人治疗小组 III 的定义评估 MS 的诊断。通过峰值扭矩与体重的比值（牛顿米每千克）和握力与体重的比值（牛顿每千克）测定膝关节伸肌的等速肌肉力量。无 MS 的参与者具有更强的腿部肌肉力量和握力与体重的比值。在我们的研究人群中，MS 对肌肉力量的影响在男性中比在女性中更为显著。仅男性显示 MS 与肌肉力量之间存在显著的交互作用（P=0.014），且 65 至 74 岁男性的影响大于 75 岁以上的男性（119.2±31.2 与 134.5±24.3 N m/kg）。在控制协变量后，MS 参与者的膝关节伸肌强度较弱（β=-90.80，P=0.003），且交互项（年龄×MS×男性性别）具有统计学意义（β=1.00，P=0.017）。代谢综合征与肌肉无力有关，这种关系在男性中尤为明显。年龄可以改变 MS 对肌肉力量的影响。患有 MS 的 65 至 74 岁男性需要全面评估肌肉力量，以预防残疾。
