Department of Family Medicine, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Postal code: 135-720, Seoul, Republic of Korea.
Arch Gerontol Geriatr. 2012 Mar-Apr;54(2):e73-6. doi: 10.1016/j.archger.2011.06.035. Epub 2011 Aug 25.
LA, altered white matter signal intensities seen on MR brain scans, has been shown to be associated with cerebrovascular risk factors and microangiopathy. Although the cerebrovascular system is also a target for sex hormones, little is known about the association between the two. In this study, we investigated the association between male sex hormone levels and LA in old men by examining free testosterone index (FTI), total testosterone, sex hormone-binding globulin (SHBG), and LA in 342 Korean men (aged 50-80 years). The odds ratios (ORs) for LA were calculated using multivariate logistic regression. The ORs (95% CIs) for LA were 1.06 (1.01-1.10) for FTI, 1.01 (0.93-1.10) for total testosterone, and 0.97 (0.94-1.01) for SHBG after adjusting for age, smoking status, alcohol intake, regular exercise, BMI, mean arterial blood pressure, resting heart rate, white blood cell counts, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, hypertension medications, diabetes medications, and hyperlipidemia medications. The results of this study indicate that high FTI is independently associated with greater prevalence of LA in older men. Accordingly, a higher FTI may be an additional surrogate marker in assessing LA.
LA，即磁共振脑扫描上可见的改变的脑白质信号强度，已被证明与脑血管危险因素和微血管病变有关。虽然脑血管系统也是性激素的靶器官，但人们对两者之间的关联知之甚少。在这项研究中，我们通过检查游离睾酮指数（FTI）、总睾酮、性激素结合球蛋白（SHBG）和 342 名韩国男性（年龄 50-80 岁）的 LA，来研究男性性激素水平与 LA 之间的关联。使用多变量逻辑回归计算 LA 的比值比（OR）。调整年龄、吸烟状况、饮酒量、规律运动、BMI、平均动脉压、静息心率、白细胞计数、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、高血压药物、糖尿病药物和高脂血症药物后，FTI 的 OR（95%CI）为 1.06（1.01-1.10），总睾酮的 OR（95%CI）为 1.01（0.93-1.10），SHBG 的 OR（95%CI）为 0.97（0.94-1.01）。这项研究的结果表明，高 FTI 与老年男性 LA 患病率增加独立相关。因此，较高的 FTI 可能是评估 LA 的另一个替代标志物。
