Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
Cytokine. 2011 Nov;56(2):471-6. doi: 10.1016/j.cyto.2011.08.013. Epub 2011 Aug 26.
Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without general symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascular occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets.
镰状细胞贫血症（SCA）是一种常见的严重单基因疾病，其特征为慢性溶血、频繁感染、慢性炎症状态和微循环反复阻塞，导致疼痛危象、器官损伤和过早死亡。本研究评估了 SCA 患者血清中 IL-18、尿酸、溶血标志物和炎症分子之间的关联。进行了一项横断面研究，包括 45 名 SCA 患者（中位年龄 20.5 岁），无全身症状且未接受输血。稳态 SCA 患者的纳入标准为无住院和无感染。白细胞介素 18 和尿酸水平与溶血标志物、内皮功能障碍和其他细胞因子水平密切相关。这些发现提示 IL-18 和尿酸可能对 SCA 中的血管闭塞的病理生理学有影响。应进行更多研究以确定类似的预后标志物和可能的治疗靶点。
