在斯里兰卡城市中，宫颈癌存档宫颈组织中人类乳头瘤病毒基因型的分布。
Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka.
机构信息
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
出版信息
Int J Gynaecol Obstet. 2011 Nov;115(2):180-2. doi: 10.1016/j.ijgo.2011.05.021. Epub 2011 Aug 27.
OBJECTIVE
To identify the contributions of various human papillomavirus (HPV) genotypes in tissue samples from women diagnosed with cervical cancer in Sri Lanka.
METHODS
In a retrospective study, archival cervical tissues samples (n=108) obtained from Sri Lankan women diagnosed with histologically proven invasive squamous cell carcinoma between 2006 and 2007 were tested for HPV. Genotyping of HPV DNA was performed using an INNO-LiPA assay.
RESULTS
Overall, 93% of tumor samples tested positive for HPV DNA. HPV types 16 and 18 accounted collectively for 83.4% of the positive samples.
CONCLUSION
The findings suggest that the HPV genotypes responsible for causing cervical cancer in Sri Lanka are similar to those reported elsewhere worldwide. Consequently, women in Sri Lanka could benefit from currently available prophylactic HPV vaccines should they be implemented.
目的
鉴定在斯里兰卡被诊断为宫颈癌的女性组织样本中各种人乳头瘤病毒（HPV）基因型的作用。
方法
在一项回顾性研究中，检测了 2006 年至 2007 年间在斯里兰卡被诊断为组织学证实的浸润性鳞状细胞癌的女性的存档宫颈组织样本（n=108）是否存在 HPV。使用 INNO-LiPA 测定法对 HPV DNA 进行基因分型。
结果
总体而言，93%的肿瘤样本 HPV DNA 检测呈阳性。HPV 16 型和 18 型共同占阳性样本的 83.4%。
结论
这些发现表明，导致斯里兰卡宫颈癌的 HPV 基因型与世界其他地方报道的相似。因此，如果实施预防性 HPV 疫苗，斯里兰卡的女性可能会从中受益。
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