Clinical Virology Department, Innovative Biotech, Keffi/Abuja, Nigeria.
Trans R Soc Trop Med Hyg. 2011 Nov;105(11):655-60. doi: 10.1016/j.trstmh.2011.08.001. Epub 2011 Aug 27.
We estimated the HIV incidence among commercial female sex workers (FSWs) in north central Nigeria using bimodal methodology. Using a cross-sectional study design, a total of 900 active FSWs between the ages of 18 and 35 years were recruited from 52 brothels within Nasarawa State, Nigeria. A rapid test algorithm was used to determine their HIV status. The BED IgG-Capture enzyme immunoassay (CEIA) was applied on the HIV-seropositive samples to detect recent HIV-1 infection for the estimation of incidence among those with HIV infection. Of the 900 FSWs tested, 335 (37.2%) were found to be positive for HIV. Of these, 63 showed evidence of recent infection. Using two third-generation BED analysis approaches that account for false-recent rate, an annualized adjusted HIV incidence of 11.97% (95% CI: 8.51-15.43%) and 12.36% (95% CI: 8.18-16.34%) was observed; difference P>0.05. In addition, 875 (97.2%) of the FSWs readily agreed to participate in HIV clinical trials. We have developed the expertise and infrastructure necessary for clinical trial investigations in sub-Saharan Africa. We have recorded a high proportion of recent HIV infections among FSWs in Nigeria and also provided an enabling environment for future studies of HIV prevention methods.
我们使用双峰法估计了尼日利亚中北部商业性女性性工作者（FSWs）中的艾滋病毒发病率。采用横断面研究设计，从尼日利亚纳萨拉瓦州的 52 个妓院招募了 900 名年龄在 18 至 35 岁之间的活跃 FSW。使用快速测试算法确定他们的 HIV 状态。BED IgG 捕获酶免疫分析（CEIA）应用于 HIV 血清阳性样本，以检测最近的 HIV-1 感染，用于估计 HIV 感染者中的发病率。在 900 名接受测试的 FSW 中，有 335 人（37.2%）HIV 呈阳性。其中 63 人显示出近期感染的证据。使用两种第三代 BED 分析方法，考虑到假近期率，年化调整后的 HIV 发病率为 11.97%（95%CI：8.51-15.43%）和 12.36%（95%CI：8.18-16.34%）；差异 P>0.05。此外，875 名（97.2%）FSWs 很乐意参与 HIV 临床试验。我们已经开发出在撒哈拉以南非洲进行临床试验研究所需的专业知识和基础设施。我们在尼日利亚记录了 FSWs 中近期 HIV 感染的高比例，并为未来的 HIV 预防方法研究提供了有利的环境。
