基于大肠杆菌素研究对膜插入的见解。

Insights into membrane insertion based on studies of colicins.

作者信息

Parker M W, Tucker A D, Tsernoglou D, Pattus F

机构信息

European Molecular Biology Laboratory, Heidelberg, FRG.

出版信息

Trends Biochem Sci. 1990 Apr;15(4):126-9. doi: 10.1016/0968-0004(90)90205-p.

DOI:10.1016/0968-0004(90)90205-p

PMID:2187292

Abstract

The recently determined three-dimensional structure of the pore-forming domain of colicin A has led to a hypothetical model for membrane insertion and channel formation. Certain features of this model have implications for understanding the mechanism of membrane insertion by other toxins and may have a broader relevance to protein transport in general.

摘要

最近确定的大肠杆菌素A成孔结构域的三维结构，引出了一个关于膜插入和通道形成的假设模型。该模型的某些特征对于理解其他毒素的膜插入机制具有启示意义，并且可能与一般的蛋白质转运有更广泛的相关性。