马来西亚精神分裂症患者 COMT 单倍型分析。
COMT haplotype analyses in Malaysians with schizophrenia.
机构信息
Department of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia.
出版信息
Psychiatry Res. 2012 Jan 30;195(1-2):83-4. doi: 10.1016/j.psychres.2011.07.039. Epub 2011 Aug 27.
Abstract
The present study included a total 261 patients with schizophrenia and 261 healthy controls to replicate the genetic association between the cathechol-o-methyltransferase gene and schizophrenia using a haplotype block-based gene-tagging. The G-G-G haplotype was found to show a highly significant association with schizophrenia.
摘要
本研究共纳入 261 例精神分裂症患者和 261 例健康对照，采用基于单体型块的基因标记技术，对儿茶酚-O-甲基转移酶基因与精神分裂症的遗传关联进行了复制。发现 G-G-G 单体型与精神分裂症显著相关。
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