Heby O, Persson L
Department of Zoophysiology, University of Umeå, Sweden.
Trends Biochem Sci. 1990 Apr;15(4):153-8. doi: 10.1016/0968-0004(90)90216-x.
The polyamines putrescine, spermidine and spermine are important cellular constituents involved in the regulation of cell growth and differentiation. Their intracellular levels are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and excretion. As a result of the application of molecular biology techniques, some of these mechanisms are presently being unravelled, and are providing a basis for the rational development of novel agents effective against proliferative disorders and various parasitic diseases.
多胺腐胺、亚精胺和精胺是参与细胞生长和分化调节的重要细胞成分。它们的细胞内水平受多种影响其合成、降解、摄取和排泄的机制调控。由于分子生物学技术的应用，目前其中一些机制正在被揭示，这为合理开发有效对抗增殖性疾病和各种寄生虫病的新型药物提供了依据。
