成人难治性继发性噬血细胞性淋巴组织细胞增生症患者行脾切除术。
Splenectomy for an adult patient with refractory secondary hemophagocytic lymphohistiocytosis.
机构信息
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300, Guangzhou Road, Nanjing, Jiangsu 210029, China.
出版信息
Biomed Pharmacother. 2011 Sep;65(6):432-5. doi: 10.1016/j.biopha.2011.04.008. Epub 2011 Jun 16.
Treatment regimens of secondary hemophagocytic lymphohistiocytosis (sHLH) are complicated and individualized. CHOP regimen is well known for the treatment of adult sHLH, but it was not so effective for the 56-year-old male patient in our study. Splenomegaly, one of clinical manifestations of HLH, has urged us to investigate the role of splenectomy in HLH patients. Splenectomy is not only beneficial to confirm the underlying diseases, but also beneficial for the treatment of HLH. Here, we present a case diagnosed as sHLH who has recovered from HLH following comprehensive treatment based on splenectomy. The therapeutic value of splenectomy in sHLH needs further study.
继发性噬血细胞性淋巴组织细胞增生症（sHLH）的治疗方案复杂且个体化。CHOP 方案是治疗成人 sHLH 的知名方案，但在我们的研究中，对于这位 56 岁的男性患者效果并不明显。脾肿大是 HLH 的临床表现之一，这促使我们研究脾切除术在 HLH 患者中的作用。脾切除术不仅有利于明确潜在疾病，也有利于 HLH 的治疗。在这里，我们报告了一例 sHLH 病例，该患者在接受基于脾切除术的综合治疗后从 HLH 中康复。脾切除术在 sHLH 中的治疗价值需要进一步研究。
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