同一患者中分离出多种非结核分枝杆菌。

Isolation of multiple nontuberculous mycobacteria species in the same patients.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea.

出版信息

Int J Infect Dis. 2011 Nov;15(11):e795-8. doi: 10.1016/j.ijid.2011.07.004. Epub 2011 Aug 27.

DOI:10.1016/j.ijid.2011.07.004

PMID:21873093

Abstract

BACKGROUND

During the observation of many patients with nontuberculous mycobacteria (NTM) infections, we have often isolated different NTM species in the same patient. In this study we elucidated the patterns of multiple NTM species isolation.

METHODS

The analysis included all patients from whom more than one species of mycobacteria were cultured from a respiratory specimen at Seoul National University Hospital, a tertiary referral hospital in South Korea, between January 2002 and December 2008. The demographic characteristics and clinical and radiographic findings were reviewed retrospectively.

RESULTS

Multiple NTM species were isolated from 37 patients. Four patients with Mycobacterium gordonae, Mycobacterium terrae, or Mycobacterium lentiflavum were excluded due to the possibility of contamination. Transition to another NTM species was observed in 23 patients (69.7%), while alternating isolation of two or three NTM species was seen in nine patients. Two species were isolated simultaneously from different sputum samples collected from one patient on the same day.

CONCLUSIONS

Different NTM species were isolated from the same patients.

摘要

背景

在观察许多非结核分枝杆菌（NTM）感染患者时，我们经常在同一患者中分离出不同的 NTM 物种。在这项研究中，我们阐明了多种 NTM 物种分离的模式。

方法

该分析包括 2002 年 1 月至 2008 年 12 月期间在韩国首尔国立大学医院（一家三级转诊医院）从呼吸道标本中培养出一种以上分枝杆菌的所有患者。回顾性审查了人口统计学特征以及临床和影像学发现。

结果

从 37 名患者中分离出多种 NTM 物种。由于可能存在污染，排除了 4 名患有戈登分枝杆菌，土分枝杆菌或微黄分枝杆菌的患者。23 名患者（69.7％）观察到向另一种 NTM 物种的转变，9 名患者观察到两种或三种 NTM 物种的交替分离。同一天从同一患者的不同痰液样本中同时分离出两种不同的 NTM 物种。