Department of Epidemiology, Medical Board, Singapore General Hospital, Singapore, Singapore.
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and kNowledge (OCEAN), Tan Tock Seng Hospital, Singapore, Singapore.
BMC Infect Dis. 2019 May 17;19(1):436. doi: 10.1186/s12879-019-3909-3.
Information on non-tuberculosis mycobacterial (NTM) diseases remains limited in Singapore and other Southeast Asian countries. This study aimed to delineate epidemiological and clinical features of pulmonary NTM disease.
A retrospective review was performed on all NTM isolates identified in Singapore General Hospital from 2012 to 2016 using the 2007 ATS/IDSA diagnostic criteria.
A total of 2026 NTM isolates from 852 patients were identified. M. abscessus-chelonae group (1010, 49.9%) was the most commonly isolated and implicated in pulmonary NTM disease. Pulmonary cases (352, 76%) had the highest prevalence among patients diagnosed with NTM diseases (465/852, 54.6%) with no gender difference. Male patients were older (68.5 years, P = 0.014) with a higher incidence of chronic obstructive pulmonary disease (COPD) (23.6%, P < 0.001) and recurrent cough with phlegm production (51.6%, P = 0.035). In contrast, more female patients had bronchiectasis (50%, P < 0.001) and haemoptysis (37.6%, P = 0.042). Age and COPD were associated with multiple NTM species isolation per patient.
M. abscessus-chelonae group was the commonest NTM species isolated in Singapore. Pulmonary NTM infection has the highest frequency with male and female patients associated with a higher incidence of COPD and bronchiectasis respectively. Age and COPD were associated with multiple NTM species isolation per patient.
非结核分枝杆菌（NTM）疾病的信息在新加坡和其他东南亚国家仍然有限。本研究旨在描绘肺 NTM 疾病的流行病学和临床特征。
对 2012 年至 2016 年期间在新加坡总医院鉴定的所有 NTM 分离株，使用 2007 年 ATS/IDSA 诊断标准进行回顾性分析。
共鉴定出 852 例患者的 2026 株 NTM 分离株。脓肿分枝杆菌-chelonae 组（1010 株，占 49.9%）是最常见的分离株，与肺 NTM 疾病有关。在诊断为 NTM 疾病的患者（465/852，54.6%）中，肺病例（352 例，占 76%）患病率最高，且无性别差异。男性患者年龄较大（68.5 岁，P=0.014），慢性阻塞性肺疾病（COPD）发病率较高（23.6%，P<0.001），反复咳嗽并伴有咳痰（51.6%，P=0.035）。相比之下，更多的女性患者患有支气管扩张症（50%，P<0.001）和咯血（37.6%，P=0.042）。年龄和 COPD 与每位患者分离出多种 NTM 物种相关。
脓肿分枝杆菌-chelonae 组是新加坡最常见的 NTM 物种。肺 NTM 感染频率最高，男性和女性患者分别与 COPD 和支气管扩张症的发病率较高有关。年龄和 COPD 与每位患者分离出多种 NTM 物种相关。
