在结直肠癌中 IGF-1 和 IGF-1R 的表达及其与临床病理因素的关系。
Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.
机构信息
Department of Surgery, Faculty of Medicine, Kurume University, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.
出版信息
Anticancer Res. 2011 Jul;31(7):2541-5.
BACKGROUND
Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer.
PATIENTS AND METHODS
A prospective study was conducted of 210 colorectal cancer patients that underwent resection from January 2002 to December 2004. The clinicopathological data was correlated to expression of IGF-1 and IGF-1R obtained from immunohistochemical analysis. Statistical analysis was carried using univariate and multivariate analysis.
RESULTS
IGF1 and IGF-1R staining was positive in 169 (80%) and 139 (66%) cases, respectively. Univariate and multivariate analyses showed significant correlation between expression of IGF-1 and tumor size (p=0.0024), and depth of invasion (p=0.0147). While IGF-1R was significantly correlated to tumor size and depth of invasion in univariate analysis, only tumor size (p=0.0658) had a strong association in multivariate analysis.
CONCLUSION
Expression of IGF-1 and IGF-1R seems to increase with tumor size in colorectal cancer.
背景
胰岛素样生长因子-1（IGF-1）和 IGF-1 受体（IGF-1R）的表达已被证明在结直肠癌中增加。我们研究了 IGF-1 和 IGF-1R 的表达与结直肠癌临床病理因素之间的相关性。
患者和方法
对 2002 年 1 月至 2004 年 12 月期间接受切除术的 210 例结直肠癌患者进行了前瞻性研究。通过免疫组织化学分析获得的临床病理数据与 IGF-1 和 IGF-1R 的表达相关联。使用单因素和多因素分析进行统计分析。
结果
IGF1 和 IGF-1R 的染色分别在 169 例（80%）和 139 例（66%）病例中呈阳性。单因素和多因素分析表明，IGF-1 的表达与肿瘤大小（p=0.0024）和浸润深度（p=0.0147）之间存在显著相关性。虽然 IGF-1R 在单因素分析中与肿瘤大小和浸润深度显著相关，但只有肿瘤大小（p=0.0658）在多因素分析中具有很强的相关性。
结论
在结直肠癌中，IGF-1 和 IGF-1R 的表达似乎随着肿瘤大小的增加而增加。
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