在中国两个汉族人群中，CCR6 多态性与白塞病易感性无关。
There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations.
机构信息
The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
出版信息
Br J Ophthalmol. 2011 Nov;95(11):1603-6. doi: 10.1136/bjophthalmol-2011-300018. Epub 2011 Aug 25.
BACKGROUND
Polymorphisms of CC chemokine receptor 6 (CCR6) genes have recently been reported to be associated with the susceptibility to several immune-related diseases. This study was conducted to examine the association of CCR6 with Behçet's disease (BD) in two Chinese Han populations.
METHODS
A total of 473 patients with BD and 725 healthy controls from two Chinese Han populations were genotyped by the PCR-restriction fragment length polymorphism method. Hardy-Weinberg equilibrium was tested using the χ(2) test. Genotype frequencies were estimated by direct counting. Allele and genotype frequencies were compared between patients and controls using the χ(2) test.
RESULTS
The genotype and allele frequencies of rs3093024, rs6902119, rs3093023 and rs2301436 were not different between patients with BD and healthy controls. Analysis according to gender and clinical findings including oral ulcer, genital ulcer, skin lesions and arthritis did not show any association of the four tested polymorphisms with these parameters.
CONCLUSIONS
The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations.
背景
CC 趋化因子受体 6（CCR6）基因的多态性最近被报道与几种免疫相关疾病的易感性有关。本研究旨在在中国两个汉族人群中研究 CCR6 与白塞病（BD）的相关性。
方法
采用 PCR-限制性片段长度多态性方法，对来自两个汉族人群的 473 例 BD 患者和 725 例健康对照者进行基因分型。采用卡方检验检验 Hardy-Weinberg 平衡。直接计数法估计基因型频率。采用卡方检验比较病例组和对照组的等位基因和基因型频率。
结果
BD 患者与健康对照组之间 rs3093024、rs6902119、rs3093023 和 rs2301436 的基因型和等位基因频率无差异。根据性别和包括口腔溃疡、生殖器溃疡、皮肤损伤和关节炎在内的临床发现进行的分析并未显示这四个检测的多态性与这些参数之间存在任何关联。
结论
在本研究的中国汉族人群中，所检测的 CCR6 基因多态性与 BD 的易感性无关。
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