Department of Radiology, Churchill Hospital, Oxford, UK.
Postgrad Med J. 2011 Nov;87(1033):746-9. doi: 10.1136/pgmj.2011.118497. Epub 2011 Aug 27.
The prevalence of incidental pulmonary emboli (PE) detected on contrast enhanced CT performed for other reasons is approximately 2.5%. The treatment decisions based upon the discovery of incidental PE have been less well reported. The purpose of this study was to report the clinician's response to, and consequences of, the finding of incidental PE on contrast enhanced CT.
Retrospective cohort study. Patients with incidental PE detected on a contrast enhanced CT were retrospectively identified at a single institution between 1 January 2009 and 31 December 2009. Case note review was performed to assess clinicians' responses to this finding. Patients with synchronous venous thromboembolism, unrecognised symptoms or factors preventing response assessment were excluded from this analysis. Patient and PE characteristics, treatment, and outcomes related to treatment and non-treatment were recorded.
There were 73 patients with incidental PE: 52 were in the proximal pulmonary arteries and 21 were distal. 16 patients were excluded from the treatment analysis. 52 of 57 (91.2%) patients were treated with therapeutic anticoagulation. There were 2 (3.8%) serious adverse events related to treatment. 5 (8.8%) patients were not treated; 2 (40%) developed recurrent venous thromboembolism. Treatment of incidental PE was not significantly associated with patient age, PE risk factors or PE location. A smaller proportion of single incidental PE were treated than multiple incidental PE (p=0.047).
There is morbidity associated with both treatment and non-treatment of incidental PE. However, despite the uncertainty about the natural history and clinical significance of incidental PE, the majority of patients at the authors' institution received prompt anticoagulation.
在因其他原因进行的增强 CT 检查中偶然发现的肺栓塞(PE)的发生率约为 2.5%。基于偶然发现的 PE 所做出的治疗决策报道较少。本研究的目的是报告偶然发现增强 CT 上的偶然发现的 PE 后临床医生的反应及其结果。
回顾性队列研究。在一家医疗机构中,回顾性地确定了 2009 年 1 月 1 日至 12 月 31 日期间因偶然发现的增强 CT 上的 PE 而进行的患者。进行病历审查以评估临床医生对这一发现的反应。从这项分析中排除了同时患有静脉血栓栓塞症、未识别的症状或有预防反应评估的因素的患者。记录患者和 PE 的特征、治疗以及与治疗和非治疗相关的结果。
共有 73 例偶然发现的 PE:52 例位于肺近端动脉,21 例位于肺远端动脉。有 16 例患者被排除在治疗分析之外。57 例患者中的 52 例(91.2%)接受了治疗性抗凝治疗。与治疗相关的严重不良事件有 2 例(3.8%)。有 5 例(8.8%)患者未接受治疗;其中 2 例(40%)发生了复发性静脉血栓栓塞症。偶然发现的 PE 的治疗与患者年龄、PE 危险因素或 PE 位置无显著相关性。单一偶然发现的 PE 比多发性偶然发现的 PE 的治疗比例更小(p=0.047)。
偶然发现的 PE 的治疗和未治疗都与发病率有关。然而,尽管对偶然发现的 PE 的自然史和临床意义存在不确定性,但作者所在机构的大多数患者都及时接受了抗凝治疗。