[宫内授精中精子顶体反应检测]

[Sperm acrosome reaction detection in intrauterine insemination].

作者信息

Zhang Ke, Fan Liqing, Gong Fei, Zhu Wenbing

机构信息

Institute of Human Reproduction and Stem Cell Engineering, Central South University, Changsha 410078, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;36(7):687-91. doi: 10.3969/j.issn.1672-7347.2011.07.018.

DOI:10.3969/j.issn.1672-7347.2011.07.018

PMID:21873797

Abstract

OBJECTIVE

To investigate the relationship between sperm acrosome reaction (AR) and the clinical pregnancy rate of intrauterine insemination (IUI).

METHODS

We detected the sperm spontaneous AR rate and Ca2+ ionophore A23187-induced AR rate in 128 patients who accepted IUI treatment, collected their clinical data and analysed the relationship between sperm AR rate and clinical pregnancy rate of IUI.

RESULTS

There was no statistical difference between the spontaneous AR rates in the pregnant group and the non-pregnant group (7.7% vs. 7.0%, P>0.05), but there was statistical difference between the induced AR rates(51.9 % vs. 43.5%, P<0.05). There was statistical difference in the clinical pregnancy rate among the 3 IUI groups divided by induced AR rate (≤20.0%, 20.1%-49.9%, and ≥50.0%; 4.8% vs. 12.5% vs. 18.6%, P<0.05).

CONCLUSION

The spontaneous AR rate has nothing to do with the clinical pregnancy rate of IUI, but the induced AR rate is associated with the clinical pregnancy rate of IUI.

摘要

目的

探讨精子顶体反应（AR）与宫腔内人工授精（IUI）临床妊娠率之间的关系。

方法

检测128例接受IUI治疗患者的精子自发AR率和钙离子载体A23187诱导的AR率，收集其临床资料，并分析精子AR率与IUI临床妊娠率之间的关系。

结果

妊娠组与未妊娠组的自发AR率无统计学差异（7.7%对7.0%，P>0.05），但诱导AR率有统计学差异（51.9%对43.5%，P<0.05）。根据诱导AR率分为3组（≤20.0%、20.1%-49.9%和≥50.0%）的IUI组临床妊娠率有统计学差异（4.8%对12.5%对18.6%，P<0.05）。