Fukumoto Shinya, Hanazono Kiwamu, Kawasaki Naomi, Hori Yasutomo, Higuchi Seiichi, Sasaki Takushi, Temma Kyosuke, Uchide Tsuyoshi
Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
J Vet Med Sci. 2012 Jan;74(1):111-5. doi: 10.1292/jvms.11-0243. Epub 2011 Aug 29.
A 7-year-old, male, mixed breed dog was referred to the Veterinary Teaching Hospital at Kitasato University because of anorexia, lameness and multiple cutaneous lesions. Observation of bone marrow plasmacytosis, osteolytic bone lesions, serum myeloma protein and cutaneous infiltration of myeloma cells led us to a diagnosis of multiple myeloma (MM) with cutaneous involvement. Polymerase chain reaction and sequence analysis for the rearranged genes of immunoglobulin and T-cell receptor demonstrated that the neoplastic cells found in skin lesions or bone marrow are of B-lymphocyte lineage and share a common original precursor cell. The dog was treated with UW-Madison protocol or melphalan/prednisone protocol and survived 175 days. This is rare case of anaplastic MM with cutaneous involvement in dog.
一只7岁的雄性杂种犬因厌食、跛行和多处皮肤病变被转诊至北里大学兽医教学医院。骨髓浆细胞增多、溶骨性骨病变、血清骨髓瘤蛋白以及骨髓瘤细胞的皮肤浸润等表现，使我们诊断该犬患有伴有皮肤受累的多发性骨髓瘤（MM）。对免疫球蛋白和T细胞受体重排基因进行聚合酶链反应和序列分析表明，在皮肤病变或骨髓中发现的肿瘤细胞属于B淋巴细胞谱系，并且有一个共同的原始前体细胞。该犬接受了威斯康星大学麦迪逊分校方案或美法仑/泼尼松方案治疗，存活了175天。这是一例犬发生间变性MM并伴有皮肤受累的罕见病例。
