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超声引导下结直肠癌肝转移的外科治疗进展。

Advances in the surgical treatment of colorectal cancer liver metastases through ultrasound.

机构信息

Liver Surgery Unit, Third Department of General Surgery, University of Milan, IRCCS Istituto Clinico Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

出版信息

Surg Today. 2011 Sep;41(9):1184-9. doi: 10.1007/s00595-010-4527-2. Epub 2011 Aug 26.

DOI:10.1007/s00595-010-4527-2
PMID:21874412
Abstract

Surgery remains the gold standard of treatment for colorectal cancer liver metastases (CLM). The only limitation of surgery for CLM is its technical feasibility, the key point being to leave enough remnant liver to ensure patient survival. This report describes a surgical procedure based extensively on ultrasound guidance, which allows for curative resection in one stage and also for multiple bilobar CLM. This strategy minimizes the need for two-stage hepatectomy and may thus overcome many of the limitations and consequences of a two-stage approach, such as the impossibility to complete the treatment approach in 20%-25% of patients and the amputation of major vascular structures, which can result in less technical solutions for CLM relapse.

摘要

手术仍然是结直肠癌肝转移(CLM)的治疗金标准。手术治疗 CLM 的唯一限制是其技术可行性,关键是要留下足够的剩余肝脏以确保患者的生存。本报告描述了一种广泛基于超声引导的手术程序,该程序允许在一个阶段进行治愈性切除,也允许对多个双侧 CLM 进行切除。这种策略最大限度地减少了两阶段肝切除术的需求,因此可能克服了两阶段方法的许多局限性和后果,例如 20%-25%的患者无法完成治疗方法和主要血管结构的截断,这可能导致针对 CLM 复发的技术解决方案减少。

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1
Advances in the surgical treatment of colorectal cancer liver metastases through ultrasound.超声引导下结直肠癌肝转移的外科治疗进展。
Surg Today. 2011 Sep;41(9):1184-9. doi: 10.1007/s00595-010-4527-2. Epub 2011 Aug 26.
2
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Minerva Chir. 2013 Feb;68(1):41-7.
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One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases: a feasible and effective alternative to the 2-stage approach.一期超声引导下肝切除术治疗多叶结直肠癌肝转移:一种可行且有效的两阶段手术替代方案。
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[Treatment strategy for multiple colorectal liver metastases: role for two-stage hepatectomy].[多发性结直肠癌肝转移的治疗策略:两阶段肝切除术的作用]
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Outcomes of enhanced one-stage ultrasound-guided hepatectomy for bilobar colorectal liver metastases compared to those of ALPPS: a multicenter case-match analysis.超声引导下两阶段增强肝切除术治疗结直肠癌肝转移的疗效优于 ALPPS:一项多中心病例匹配分析。
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引用本文的文献

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Parenchymal-sparing hepatectomies (PSH) for bilobar colorectal liver metastases are associated with a lower morbidity and similar oncological results: a propensity score matching analysis.用于双侧结直肠癌肝转移的保留肝实质肝切除术(PSH)与较低的发病率和相似的肿瘤学结果相关:一项倾向评分匹配分析
HPB (Oxford). 2016 Sep;18(9):781-90. doi: 10.1016/j.hpb.2016.06.004. Epub 2016 Jul 5.
2
Is intraoperative ultrasound still useful for the detection of colorectal cancer liver metastases?术中超声对结直肠癌肝转移的检测仍有用吗?
HPB (Oxford). 2015 Jun;17(6):514-9. doi: 10.1111/hpb.12393. Epub 2015 Feb 28.
3
Clinical significance of and future perspectives for hepatic arterial infusion chemotherapy in patients with liver metastases from colorectal cancer.

本文引用的文献

1
Intraoperative ultrasonographic detection of communicating veins between adjacent hepatic veins during hepatectomy for tumours at the hepatocaval confluence.肝门汇合部肿瘤行肝切除术中毗邻肝静脉间交通静脉的术中超声检测。
Br J Surg. 2010 Dec;97(12):1867-73. doi: 10.1002/bjs.7230. Epub 2010 Aug 26.
2
Assessment of SMAD4, p53, and Ki-67 alterations as a predictor of liver metastasis in human colorectal cancer.评估 SMAD4、p53 和 Ki-67 的改变作为预测人结直肠癌肝转移的指标。
Surg Today. 2010 Mar;40(3):245-50. doi: 10.1007/s00595-009-4028-3. Epub 2010 Feb 24.
3
One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases: a feasible and effective alternative to the 2-stage approach.
结直肠癌肝转移患者肝动脉灌注化疗的临床意义及展望
Surg Today. 2013 Oct;43(10):1088-94. doi: 10.1007/s00595-012-0416-1. Epub 2012 Nov 10.
4
Impact of the VIO system in hepatic resection for patients with hepatocellular carcinoma.VIO 系统对肝癌患者肝切除手术的影响。
Surg Today. 2012 Dec;42(12):1176-82. doi: 10.1007/s00595-012-0306-6. Epub 2012 Sep 20.
一期超声引导下肝切除术治疗多叶结直肠癌肝转移:一种可行且有效的两阶段手术替代方案。
Surgery. 2009 Jul;146(1):60-71. doi: 10.1016/j.surg.2009.02.017.
4
Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases.不可切除的结直肠癌肝转移灶两阶段肝切除术的长期结果
Ann Surg. 2008 Dec;248(6):994-1005. doi: 10.1097/SLA.0b013e3181907fd9.
5
Hepatectomy for stage B and stage C hepatocellular carcinoma in the Barcelona Clinic Liver Cancer classification: results of a prospective analysis.巴塞罗那临床肝癌分期中B期和C期肝细胞癌的肝切除术:一项前瞻性分析结果
Arch Surg. 2008 Nov;143(11):1082-90. doi: 10.1001/archsurg.143.11.1082.
6
Systematic extended right posterior sectionectomy: a safe and effective alternative to right hepatectomy.系统性扩大右后叶切除术:一种安全有效的右肝切除术替代方案。
Ann Surg. 2008 Apr;247(4):603-11. doi: 10.1097/SLA.0b013e31816387d7.
7
Predictors of survival after hepatic resection among patients with colorectal liver metastasis.结直肠癌肝转移患者肝切除术后的生存预测因素。
Br J Cancer. 2007 Dec 17;97(12):1606-12. doi: 10.1038/sj.bjc.6604093. Epub 2007 Dec 11.
8
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The role and limitations of 18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) scan and computerized tomography (CT) in restaging patients with hepatic colorectal metastases following neoadjuvant chemotherapy: comparison with operative and pathological findings.18-氟-2-脱氧-D-葡萄糖正电子发射断层扫描(FDG-PET)和计算机断层扫描(CT)在新辅助化疗后肝结直肠癌转移患者再分期中的作用及局限性:与手术和病理结果的比较
J Gastrointest Surg. 2007 Apr;11(4):472-8. doi: 10.1007/s11605-006-0032-8.
10
Contrast-enhanced intraoperative ultrasonography during surgery for hepatocellular carcinoma in liver cirrhosis: is it useful or useless? A prospective cohort study of our experience.肝硬化患者肝细胞癌手术中对比增强术中超声检查:有用还是无用?基于我们经验的前瞻性队列研究
Ann Surg Oncol. 2007 Apr;14(4):1347-55. doi: 10.1245/s10434-006-9278-3. Epub 2007 Jan 26.