精神疾病动物模型中的磁共振成像

MRI in animal models of psychiatric disorders.

作者信息

Poole Dana S, Oitzl Melly S, van der Weerd Louise

机构信息

Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

出版信息

Methods Mol Biol. 2011;771:309-35. doi: 10.1007/978-1-61779-219-9_17.

DOI:10.1007/978-1-61779-219-9_17

PMID:21874486

Abstract

Here we describe MRI and (1)H MRS protocols for the investigation of animal models (mainly mice and rats) of psychiatric disorders. The introduction provides general findings from brain imaging studies in patients with psychiatric diseases and refers to general rules regarding the use of animal models in research. The methods section includes a selection of basic 9.4 T MRI and MRS protocols applicable for the investigation of animal models of psychiatric disorders (T1W, T2W, FLAIR, (1)H MRS). The notes section discusses in detail a series of factors that can influence the outcome of the experiment: from animal handling, stress-triggering aspects, and experimental design-related factors to technical aspects that affect T (1) and T (2) measurements.

摘要

在此，我们描述了用于研究精神疾病动物模型（主要是小鼠和大鼠）的MRI和氢质子磁共振波谱（¹H MRS）方案。引言部分介绍了精神疾病患者脑成像研究的一般结果，并提及了研究中使用动物模型的一般规则。方法部分包括一系列适用于研究精神疾病动物模型的基本9.4 T MRI和MRS方案（T1加权成像、T2加权成像、液体衰减反转恢复序列、¹H MRS）。注释部分详细讨论了一系列可能影响实验结果的因素：从动物处理、应激触发因素、与实验设计相关的因素到影响T1和T2测量的技术因素。