Hogers Bianca
Department of Anatomy, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Methods Mol Biol. 2011;771:579-93. doi: 10.1007/978-1-61779-219-9_30.
Non-invasive imaging of embryonic development has been an ultimate goal for embryologists for many years. Due to advances in MRI hardware and software, the extremely high spatial resolution necessary to study embryos can now be obtained. Fixed embryos can be scanned to visualize the complex 3D morphology of the developing embryo in great detail, sometimes referred to as MR histology. As the sample remains intact, it is a suitable tool for the study of rare specimens, or for screening of huge numbers of transgenic embryos. In vivo MRI can be used for time course studies of either normal development or the progression of congenital malformations.
多年来，胚胎发育的无创成像一直是胚胎学家的终极目标。由于磁共振成像（MRI）硬件和软件的进步，现在已经能够获得研究胚胎所需的极高空间分辨率。固定后的胚胎可以进行扫描，以极其详细地可视化发育中胚胎的复杂三维形态，有时也称为MR组织学。由于样本保持完整，它是研究稀有标本或筛选大量转基因胚胎的合适工具。活体MRI可用于正常发育或先天性畸形进展的时间进程研究。
