Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, People's Republic of China.
Med Oncol. 2012 Sep;29(3):1643-7. doi: 10.1007/s12032-011-0053-3. Epub 2011 Aug 28.
Cancerous inhibitor of protein phosphatase 2A (CIP2A) and survivin are aberrantly expressed in a wide range of human cancers, including lung tumors. In order to assess the expressions of these two proteins in Chinese non-small-cell lung cancer (NSCLC) patients and determine their correlation with prognosis, NSCLC tissues and adjacent non-cancerous normal lung tissues were collected from 97 patients undergoing surgical treatment and evaluated by immunohistochemistry staining. CIP2A or survivin immunoreactivity was detected in significantly more NSCLC tissues than in adjacent non-cancerous lung tissues (P < 0.05). Moreover, CIP2A expression in NSCLC correlated with TNM stage, while survivin expression correlated with TNM stage and lymph node metastasis. Kaplan-Meier survival analysis showed that the overall survival times in patients expressing either CIP2A or survivin protein in NSCLC were shorter. COX regression analysis indicated that expression of CIP2A protein was an independent prognostic factor for NSCLC patients (HR = 3.631, P = 0.015). Therefore, CIP2A expression in Chinese NSCLC patients may be a useful biomarker of biological malignancy.
癌性蛋白磷酸酶 2A 抑制剂（CIP2A）和存活素在广泛的人类癌症中异常表达，包括肺癌肿瘤。为了评估这两种蛋白在中国非小细胞肺癌（NSCLC）患者中的表达，并确定它们与预后的相关性，对 97 例接受手术治疗的 NSCLC 患者的肿瘤组织和相邻非癌性正常肺组织进行了收集，并通过免疫组织化学染色进行了评估。CIP2A 或存活素免疫反应性在 NSCLC 组织中明显比在相邻的非癌性肺组织中更为显著（P<0.05）。此外，CIP2A 在 NSCLC 中的表达与 TNM 分期相关，而存活素的表达与 TNM 分期和淋巴结转移相关。Kaplan-Meier 生存分析显示，在 NSCLC 中表达 CIP2A 或存活素蛋白的患者的总生存时间较短。COX 回归分析表明，CIP2A 蛋白的表达是 NSCLC 患者的独立预后因素（HR=3.631，P=0.015）。因此，中国 NSCLC 患者中 CIP2A 的表达可能是一种有用的生物学恶性标志物。
