Vulić Marko, Strinić Tomislav, Buković Damir, Tomić Snjezana, Zupić Tomislav, Pavić Mato, Turcić Petra, Mihaljević Slobodan
University of Split, Split University Hospital Center, Department of Obstetrics and Gynecology, Split, Croatia.
Coll Antropol. 2010 Dec;34(4):1411-4.
Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The aim of this study was to compare collagen metabolism by measuring matrix metalloproteinase-1 (MMP-1) expression in uterosacral ligament tissues of postmenopausal women with and without genital prolapse. Uterosacral ligament tissues were obtained at the time of abdominal or vaginal surgery from twenty-four patients with pelvic organ prolapse (POP) and 21 women who underwent gynecologic surgery for benign indications. The tissue samples were analyzed by immunohistochemistry. There were no differences in age, BMI and parity between two groups. The patients with genital prolapse demonstrated significantly higher occurences of MMP-1 expression compared to controls. These findings indicate that increased MMP-1 expression in uterosacral ligaments is associated with genital prolapse. Our data are consistent with the theory that increased collagen breakdown may play an important role in the onset and development of pelvic organ prolapse (POP).
生殖器脱垂女性的盆腔器官组织中胶原蛋白代谢发生改变。本研究的目的是通过测量绝经后有或无生殖器脱垂女性的子宫骶韧带组织中基质金属蛋白酶-1（MMP-1）的表达来比较胶原蛋白代谢情况。在腹部或阴道手术时从24例盆腔器官脱垂（POP）患者和21例因良性指征接受妇科手术的女性中获取子宫骶韧带组织。通过免疫组织化学分析组织样本。两组之间在年龄、体重指数和产次方面没有差异。与对照组相比，生殖器脱垂患者中MMP-1表达的发生率显著更高。这些发现表明子宫骶韧带中MMP-1表达增加与生殖器脱垂有关。我们的数据与胶原蛋白分解增加可能在盆腔器官脱垂（POP）的发生和发展中起重要作用这一理论一致。
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