Ⅰ型胶原和基质金属蛋白酶-1在有和无盆腔器官脱垂的女性的子宫骶韧带中的表达差异。
Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse.
机构信息
Department of Gynaecology and Obstetrics, University Hospital Split, School of Medicine, University of Split, Spincica 1, 21 000 Split, Croatia.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2011 Apr;155(2):225-8. doi: 10.1016/j.ejogrb.2010.12.019. Epub 2011 Jan 19.
OBJECTIVE
To compare the expression of collagen type I and matrix metalloproteinase-1 (MMP-1) in uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP).
STUDY DESIGN
Uterosacral ligament biopsies were obtained from women with POP (n=46) and control subjects (n=49). Immunohistochemistry for collagen type I and MMP-1 was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. Statistical Package for the Social Sciences Version 13.0 was used for statistical analysis.
RESULTS
The expression of collagen type I (p=0.034) and MMP-1 (p=0.038) differed between women with POP and control subjects. There was increased expression of MMP-1 and decreased expression of collagen type 1 in uterosacral ligaments of women with POP compared with control subjects.
CONCLUSIONS
This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and MMP-1 in uterosacral ligaments.
目的
比较患有和不患有盆腔器官脱垂（POP）的女性的子宫骶骨韧带活检组织中 I 型胶原和基质金属蛋白酶-1（MMP-1）的表达。
研究设计
从患有 POP（n=46）和对照组女性（n=49）中获取子宫骶骨韧带活检组织。对福尔马林固定和石蜡包埋的切片进行 I 型胶原和 MMP-1 的免疫组织化学染色。两组在年龄、体重指数、产次和绝经状态方面相匹配。使用社会科学统计软件包 13.0 进行统计分析。
结果
患有 POP 的女性与对照组女性的 I 型胶原（p=0.034）和 MMP-1（p=0.038）的表达存在差异。与对照组相比，患有 POP 的女性的子宫骶骨韧带有 MMP-1 的表达增加和 I 型胶原的表达减少。
结论
这种差异表明 POP 与子宫骶骨韧带中 I 型胶原和 MMP-1 的免疫组织化学表达之间可能存在关系。
Zotero 插件