Lafzi Ardeshir, Chitsazi Mohammad Taghi, Farahani Ramin Mostofi Zadeh, Faramarzi Masoumeh
Department of Periodontics, Tabriz University of Medical Science, Tabriz, Iran.
Am J Dent. 2011 Jun;24(3):143-7.
To evaluate the clinical efficiency of the coronally advanced flap (CAF) with and without plasma rich in growth factors (PRGF) in the management of gingival recession defects.
20 bilateral similar recession defects in six healthy non-smoker subjects were included in the present study. The test sites received PRGF as an adjunct to the coronally advanced flap (CAF) while the control sites were treated with CAF only. The clinical parameters including recession depth (RD), percentage of root coverage (RC), recession width (RW), mucogingival junction position (MGJ), width of keratinized tissue (WKT), clinical attachment level (CAL), and probing depth (PD) were measured at the baseline, 1, and 3 months post-operatively. The data were analyzed using Wilcoxon signed rank and Mann-Whitney U tests.
After 3 months, the mean root coverage was 43 +/- 34.9% in the CAF group and 61 +/- 23.5%) in the CAF + PRGF. Both treatment protocols led to a significant improvement in all measured variables compared to the baseline values, except the width of keratinized tissue. While PRGF enhanced the outcomes of CAF especially throughout the first month post-operatively, it offered no clinical advantage over CAF alone during the subsequent 2 months.
评估在治疗牙龈退缩缺损时，使用和不使用富含生长因子的血浆（PRGF）的冠向推进瓣（CAF）的临床疗效。
本研究纳入了6名健康非吸烟受试者的20个双侧相似退缩缺损。试验部位在冠向推进瓣（CAF）基础上使用PRGF，而对照部位仅接受CAF治疗。在基线、术后1个月和3个月测量包括退缩深度（RD）、牙根覆盖百分比（RC）、退缩宽度（RW）、黏膜牙龈交界位置（MGJ）、角化组织宽度（WKT）、临床附着水平（CAL）和探诊深度（PD）等临床参数。使用Wilcoxon符号秩检验和Mann-Whitney U检验分析数据。
3个月后，CAF组的平均牙根覆盖为43±34.9%，CAF+PRGF组为61±23.5%。与基线值相比，两种治疗方案均使所有测量变量有显著改善，但角化组织宽度除外。虽然PRGF尤其在术后第一个月增强了CAF的效果，但在随后的2个月中，与单独使用CAF相比，它没有临床优势。
