Exploristics Limited, Cromac Square, Belfast BT28LA, United Kingdom.
Drug Discov Today. 2011 Oct;16(19-20):862-6. doi: 10.1016/j.drudis.2011.08.008. Epub 2011 Aug 22.
Pharmacogenetics (PGx) is increasingly used as a way to target treatment to patients who are most likely to benefit. To date, PGx has shown clinical significance across a few applications but widespread use has been limited by the need for further technical, methodological and practical advances and for educating clinical researchers on the value of PGx. Here, I describe the current scope of PGx research, including recent contributions to prospective study design. A case study is included to demonstrate the limitations of current practice and to describe some practical steps for improving the chances of identifying genetic effects. Additionally, I describe some opportunities for the integration and application of disparate data sources in exploratory PGx research.
药物遗传学（PGx）越来越多地被用作将治疗方法针对最有可能受益的患者的一种方法。迄今为止，PGx 在少数几个应用中显示出了临床意义，但由于需要进一步的技术、方法和实际进展，以及需要教育临床研究人员了解 PGx 的价值，因此其广泛应用受到限制。在这里，我描述了 PGx 研究的当前范围，包括最近对前瞻性研究设计的贡献。案例研究包括描述当前实践的局限性，并描述一些实用步骤，以提高识别遗传效应的机会。此外，我还描述了在探索性 PGx 研究中整合和应用不同数据源的一些机会。
