Department of Radiology, Virgen de la Arrixaca University Hospital, 30120 El Palmar, Murcia, Spain.
J Ultrasound Med. 2011 Sep;30(9):1241-6. doi: 10.7863/jum.2011.30.9.1241.
The purpose of this study was to evaluate the effect of intra-articular injection of SonoVue (sulfur hexafluoride with a phospholipid shell; Bracco SpA, Milan, Italy) on the synovial membrane in an animal model.
Twenty-one New Zealand White rabbits (42 knees) were used in this study. We injected the knees with normal saline (saline group; n = 21) and SonoVue (SonoVue group; n = 21). A histologic examination of the knees was performed out at 3 and 12 hours and 3, 7, 15, 30, and 45 days after injection. Four histologic parameters (synovial hyperplasia, synovial stroma, vascular dilatation, and inflammatory infiltrates) were graded separately.
We found no significant differences in this study for synovial hyperplasia, vascular dilatation, or inflammatory infiltrates between the saline and SonoVue groups. A significant difference was only observed for synovial stroma (P < .05), and most of the histologic changes were mild in the saline group and moderate in the SonoVue group. The histologic changes observed in this study are considered transitory and reversible.
The results suggest that intra-articular injection of SonoVue is a safe procedure.
本研究旨在评估 SonoVue（含磷脂壳的六氟化硫）关节内注射对动物模型滑膜的影响。
本研究使用了 21 只新西兰大白兔（42 个膝关节）。我们向膝关节注射生理盐水（盐水组，n=21）和 SonoVue（SonoVue 组，n=21）。在注射后 3、12 小时以及 3、7、15、30 和 45 天，对膝关节进行组织学检查。分别对滑膜增生、滑膜基质、血管扩张和炎症浸润这四个组织学参数进行分级。
在本研究中，我们未发现盐水组和 SonoVue 组之间在滑膜增生、血管扩张或炎症浸润方面有显著差异。仅滑膜基质存在显著差异（P<.05），且盐水组的大部分组织学变化为轻度，而 SonoVue 组为中度。本研究中观察到的组织学变化被认为是短暂和可逆的。
结果表明，关节内注射 SonoVue 是一种安全的操作。
