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抗中性粒细胞胞浆抗体相关性血管炎的一种不寻常表现:组织病理学与临床表现之间的差异

An unusual presentation of antineutrophil cytoplasmic antibody-associated vasculitis: discrepancy between histopathology and clinical presentation.

作者信息

Sanavi Suzan, Afshar Reza

机构信息

Clinical Department, University of Social Welfare and Rehabilitation Sciences, Akhavan Center, Tehran, Iran.

出版信息

Iran J Kidney Dis. 2011 Sep;5(5):347-50.

Abstract

A 60-year-old man was admitted to our clinic with dyspnea, hemoptesis, anuria, nephritic syndrome, and a positive myeloperoxidase antineutrophil cytoplasmic antibody titer. He was diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis due to Wegener granulomatosis, microscopic polyangiitis, or drug induction. Unexpectedly, histopathologic examination of the kidney biopsy specimen revealed the diagnosis of noncrescentic and nonnecrotizing glomerulonephritis. We report this case because of the unusual histologic type of renal involvement.

摘要

一名60岁男性因呼吸困难、咯血、无尿、肾病综合征以及髓过氧化物酶抗中性粒细胞胞浆抗体滴度阳性入住我院。他被诊断为抗中性粒细胞胞浆抗体相关性血管炎,病因可能是韦格纳肉芽肿、显微镜下多血管炎或药物诱导。出乎意料的是,肾活检标本的组织病理学检查显示诊断为非新月体性和非坏死性肾小球肾炎。由于肾脏受累的组织学类型不寻常,我们报告了此病例。

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