Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Eye Contact Lens. 2012 Mar;38(2):130-2. doi: 10.1097/ICL.0b013e31822c3703.
The aim of the study was to report a case of Trichosporon asahii in a patient with a type I Boston keratoprosthesis and contact lens with review of the literature.
A case report and literature review are provided.
A 70-year-old monocular South Asian man with light perception vision and dense corneal scarring from previously failed amniotic membrane grafting and one failed corneal transplant was evaluated for a keratoprosthesis for visual rehabilitation. Three months after undergoing uneventful implantation of a type I Boston keratoprosthesis and placement of a therapeutic contact lens, he was found on routine follow-up to have a corneal infiltrate that was culture positive for T. asahii. The fungal keratitis was successfully treated with topical amphotericin B and oral ketoconazole.
Contact lens wear is a known risk factor for fungal keratitis. Trichosporon is an uncommon agent of fungal keratitis. We report the first known case of fungal keratitis caused by T.asahii in a patient with a keratoprosthesis and contact lens.
本研究旨在报告一例波士顿 I 型角膜假体和接触镜患者感染近平滑念珠菌的病例，并对文献进行回顾。
提供了一份病例报告和文献回顾。
一名 70 岁的单眼南亚男性，因先前的羊膜移植和一次角膜移植失败导致光感视力和密集的角膜瘢痕而接受角膜假体手术以恢复视力。在成功植入波士顿 I 型角膜假体和佩戴治疗性接触镜 3 个月后，在常规随访中发现他的角膜有浸润，经培养证实为近平滑念珠菌。真菌性角膜炎经局部两性霉素 B 和口服酮康唑成功治疗。
戴接触镜是真菌性角膜炎的已知危险因素。近平滑念珠菌是一种不常见的真菌性角膜炎病原体。我们报告了首例与角膜假体和接触镜相关的由近平滑念珠菌引起的真菌性角膜炎病例。
